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Unprecedented Relaxivity Gap in pH-Responsive Fe(III)-Based MRI Probes
Des nouvelles de l'Axe 2
Two mononuclear ferric complexes are reported that respond to a pH change with a 27- and 71-fold jump, respectively, in their capacity to accelerate the longitudinal relaxation rate of water-hydrogen nuclei, and this starting from a negligible base value of only 0.06. This unprecedented performance bodes well for tackling the sensitivity issues hampering the development of Molecular MRI. The two chelates also excel in the fully reversible and fatigue-less nature of this phenomenon.
This work is published in Angewandte Chemie