Chemistry & Life sciences

Animated by  Natacha Gillet

The "Chemistry & Live Science" theme focuses on the development of specific chemical objects able to interact with biological systems for different purposes: imaging modalities (MRI, photo-acoustic, spectral scanner with photon counting, biphotonic and fluorescence microscopy), tumour treatment by photodynamic or radiotherapy, protein crystallisation, molecular biomarkers, etc. The considered chemical objects include organic molecules, lanthanide complexes, metallic, organic or hybrid nanoparticles. Our approaches start from the synthesis and engineering of systems at different scales (from molecules to nanomaterials) to reach the in vivo application via our collaborations with biologists and physicians, through the physico-chemical and photochemical characterization of the different objects as well as the modelling of their interactions with biomolecules by computational chemistry approaches.

EVENTS

• 20th Congress of the European Society for Photobiology

PROJECTS

• SCAN n TREAT FET Open project
• SPARTE FET Open project: https://www.sparte-project.eu/
• CALYPSO Project (Ligue contre le cancer)
• ANR LANTEN
• ANR MAP
• CrystFrag Project

GDR and Scientific Group

• GDR AIM http://gdraim.cnrs-orleans.fr/
• CenTRA  https://felements.fr/cs2fe-2022/

PUBLICATIONS

• Molecular Sensors Operating by a Spin‐State Change in Solution: Application to Magnetic Resonance Imaging.
  Jérémy Salaam, Madleen Rivat, Thibaut Fogeron, Jens Hasserodt.
  Analysis & Sensing 2021, 1(1), 11 − 29.
  http://doi.org/10.1002/anse.202000015
• Hybrid multimodal contrast agent for multiscale in vivo investigation of neuroinflammation.
  Szilvia Karpati, Violaine Hubert, Ines Hristovska, Frédéric Lerouge, Frédéric Chaput, Yann Bretonnière, Chantal Andraud, Akos Banyasz, Guillaume Micouin, Maëlle Monteil, Marc Lecouvey, Marion Mercey-Ressejac, Arindam K. Dey, Patrice N. Marche, Mikael Lindgren, Olivier Pascual, Marlène Wiart, Stéphane Parola.
  Nanoscale 2021, 13(6), 3767 - 3781. https://pubs.rsc.org/en/content/articlelanding/2021/NR/D0NR07026B
• Pyclen-Based Ln(III) Complexes as Highly Luminescent Bioprobes for In Vitro and In Vivo One- and Two-Photon Bioimaging Applications.
  Nadège Hamon, Amandine Roux, Maryline Beyler, Jean-Christophe Mulatier, Chantal Andraud,Christophe Nguyen, Marie Maynadier, Nadir Bettache, Alain Duperray, Alexei Grichine,Sophie Brasselet, Magali Gary-Bobo, Olivier Maury, Raphaël Tripier.
  J. Am. Chem. Soc. 2020, 142, 10184 − 10197. https://dx.doi.org/10.1021/jacs.0c03496?ref=pdf
• Hybrid Nano-GdF₃ contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification.
  Niki Halttunen, Frédéric Lerouge, Frédéric Chaput, Marc Vandamme, Szilvia Karpati, Salim Si-Mohamed, Monica Sigovan, Loïc Boussel, Emmanuel Chereul, Philippe Douek, Stéphane Parola.
  Sci. Rep. 2019, 9(1), 1 - 8. https://www.nature.com/articles/s41598-019-48641-z
• Synthesis of the New Cyanine-Labeled Bacterial Lipooligosaccharides for Intracellular Imaging and in VitroMicroscopy Studies.
  Tung-Cheng Wang, Florent Cochet, Fabio Alessandro Facchini, Lenny Zaffaroni, Christelle Serba, Simon Pascal, Chantal Andraud, Andrea Sala, Flaviana Di Lorenzo, Olivier Maury,Thomas Huser, Francesco Peri.
  Bioconjugate Chem. 2019, 30, 1649 − 1657. http://dx.doi.org/10.1021/acs.bioconjchem.9b00044
• Unveiling the Binding Modes of the Crystallophore, a Terbium based Nucleating and Phasing Molecular Agent for Protein Crystallography.
  Sylvain Engilberge, François Riobé, Tristan Wagner, Sebastiano Di Pietro,Cécile Breyton, Bruno Franzetti, Seigo Shima, Eric Girard, Elise Dumont, Olivier Maury.
  Chem. Eur. J. 2018, 24, 9739 − 9746. https://doi.org/10.1002/chem.201802172
• Two-Photon Fluorescence and Magnetic Resonance Specific Imaging of Aβ Amyloid Using Hybrid Nano-GdF₃ Contrast Media.
  Francis Mpambani, Andreas K. O. Aslund, Frédéric Lerouge, Sofie Mystrom, Nina Reitan, Else Marie Huuse, Marius Wideroee, Frédéric Chaput, Cyrille Monnereau, Chantal Andraud,Marc Lecouvey, Susann Handrick, Stephan Prokop, Frank L. Heppner, Peter Nilsson, Per Hammarstom, Mikael Lindgren, Stéphane Parola.
  ACS Applied Bio Materials 2018, 1(2), 462 − 472. https://pubs.acs.org/doi/10.1021/acsabm.8b00191