Accueil du site > Animations Scientifiques > Séminaires 2009 > Tapas K. Kundu — Acetylation of Histones and Histone Chaperones in Cancer Manifestation : Implications in Therapeutics
Tapas K. Kundu — Acetylation of Histones and Histone Chaperones in Cancer Manifestation : Implications in Therapeutics
Speaker :
Tapas K. Kundu, Transcription an Disease Laboratory and, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
When :
Wednesday 27 May at 11am.
Where :
Salle 118
Title :
Acetylation of Histones and Histone Chaperones in Cancer Manifestation : Implications in Therapeutics
Abstract :
Altered histone acetylation pattern is associated with several diseases including cancer. The dysfunction of histone deacetylases (HDACs) and the consequent hypoacetylation of histone as well as nonhistone proteins have been causally related to cancer manifestation. However, we observed that histones are hyperacetylated in the oral cancer cell line. This observation lead us to investigate the status of histones and histone chaperone NPM1 acetylation in oral cancer patient samples. In agreement with the cell line based data, both were found to be dramatically hyperacetylated in all the grade II oral cancer sample tested. We further investigated the molecular mechanisms behind the hyperacetylation and also explore the possibility of targeting the acetyltransferase, p300 by a water soluble, small molecule inhibitor to control tumor progression.
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