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Matthieu Piel — Cell migration under confinement : from physical constraints to biological functions
Speaker :
Matthieu Piel, Institut Curie, Paris
When :
Wednesday 1 February at 11h
Were :
C023 (RDC LR6 côté Centre Blaise Pascal)
Title :
Cell migration under confinement : from physical constraints to biological functions, the case of dendritic cells, sentinelles of the immune system.
Abstract :
Dendritic cells patrol peripheral tissues like skin to look for antigen and pathogens. To achieve their function, they have to migrate between other cells or through dense extra-cellular matrix like the basal layer, without disrupting tissues, while also uptaking large amounts of material and filtering it to concentrate relevant molecules. Their migration capacity involves large deformation of the cell body and of the cell nucleus. I will present recent data we obtained on this particular mode of migration, in particular the interplay between confinement and adhesion, and the deformation of the nucleus. In a second part I will present results showing that migration and antigen uptake are tightly linked functions in these cells, leading to alternating phases of fast movement and phases of high uptake. I will end with speculation on the nature of dendritic cell trajectories and optimization of scanning of space by these cells.
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