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Accueil du site > Animations Scientifiques > Séminaires 2012 > Mathieu Boulard - TRIM28 Represses Methylated Promoters and Enforces Monoallelic Expression of Imprinted Genes
Mathieu Boulard - TRIM28 Represses Methylated Promoters and Enforces Monoallelic Expression of Imprinted Genes
Speaker : Mathieu Boulard, Department of Genetics and Development College of Physicians and Surgeons of Columbia University, New York
When : Wednesday 19 december
Where : Salle CO23 (grande salle de réunions du CBP rez-de-chaussée LR6)
Title : TRIM28 Represses Methylated Promoters and Enforces Monoallelic Expression of Imprinted Genes
Methylation of CpG dinucleotides within proximal promoters and at imprinting control regions causes heritable epigenetic silencing of transcription through an unknown mechanism. Conditional deletion of Trim28 (also known as Kap1 or Tif1) has been reported to induce transcription of retrotransposons of the intracisternal A particle (IAP) class. We report here that a strong hypomorphic allele of Trim28 causes the reactivation of IAP retrotransposon transcription without significant demethylation of proviral DNA. Imprinted genes were found to display biallelic expression in the Trim28 mutant embryos, again in the absence of methylation abnormalities. TRIM28 is the first factor shown to be essential for the repression of methylated promoters and for the monoallelic expression of normally methylated imprinting control regions.
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