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Accueil du site > Animations Scientifiques > Séminaires 2007 > Distinct roles of core histones, histone variants and linker histones in chromatin function
Distinct roles of core histones, histone variants and linker histones in chromatin function
par Webmaster - 6 septembre 2007
Orateur :
Woojin An, Biochemistry and Molecular Biology, University of Southern California, Los Angeles
Salle :
117
Sujet :
The DNA in eukaryotic cells is hierarchically packaged by the four core histones H2A, H2B, H3 and H4 to form the highly repressive structure of chromatin. Regulation of DNA-dependent processes within this chromatin context requires remodeling activities that counterbalance this repressive nature of chromatin. Three major remodeling processes that regulate DNA accessibility in chromatin are posttranslational modifications of histone N-terminal tails, binding of linker histone histone H1, and exchange of histone variants into and out of chromatin. Our goals are, using various biochemical approaches, to identify the molecular mechanisms controlling these epigenetic processes and to regulate these sophisticated processes to ensure proper chromatin function. I will present our recent data demonstrating that distinct factors are involved in regulating histone tail-mediated transcriptional activation, H1-induced transcriptional repression and H2AX exchange.
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