Partenaires
Rechercher
Accueil du site > Animations Scientifiques > Séminaires 2008 > Maintenance of genome integrity during DNA replication in yeast and in human cells
Maintenance of genome integrity during DNA replication in yeast and in human cells
Orateur(s) :
Philippe Pasero, Institut de Génétique Humaine (IGH), CNRS, Montpellier
Sallle :
Quand :
10/12/2008 à 11:00
Resumé :
A central question in cancer biology is how genomic instability arises in normal cells. Recent evidence indicates that replication stress is detected very early during the cancer process and contributes to the development of the disease. Our research focuses on the origin of this replication stress in yeast and in human cells. We use powerful new technologies such as DNA combing and ChIP-on-chip to monitor replication fork arrest and recovery at the level of individual molecules and on a genome-wide basis. These studies should provide new insights into how DNA replication errors promote the development of cancer and of other genetic disorders associated with increased genomic instability.
Dans la même rubrique :
- Morphological analysis of slow and fast muscle cells in zebrafish embryos
- Modèles minimaux pour le mouvement collectif
- Epigenetic inheritance of chromatin states in fission yeast
- HAT MODULATORS (Activators and Inhibitors) : IMPLICATIONS IN NANOBIOTECHNOLOGY
- Exploitation de nanosondes en AFM : Dynamique d’un nanoménisque accroché à une Nano aiguille de silice et fluctuations de contact d’un Nanotube de Carbone
- Epigenetic programming of mesenchymal stem cells from adipose tissue
- The Genomic Code for Nucleosome Positioning
- Nuclear organization and transcription in budding yeast
- Nouvel arExperiments on cytoskeletal and “Recombinase” motors
- Modelling chromosome replication in S. cerevisiae
- Chromatin remodeling during early development : which role for HIRA in Drosophila ?
- SPR characterization of proteonucleic self-assemblies
- The mechanics behind plant development : a pluridisciplinary view
- AEVOL : An Artificial Evolution model to unravel the effect of indirect selection on genomes structure
- Regulation of HIV-1 integration by chromatin structure and LEDGF/p75 protein, in vitro studies
- Biological strategies of motility
- Quantitative predictions for DNA two-dimensional display according to size and nucleotide sequence composition
- The Phosphoproteome of the Budding Yeast Centrosome
- Transferts d’énergie dans les protéines ; conception rationelle de protéines extrêmophiles
- The RAFT process, a “living” polymerization : a new step towards well-designed polymer architectures
