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Spatial genome organization and DNA repair
Located in Teams / Genome mechanics - A. Piazza / Research
Condensin in the context of chromatin - P. Bernard
Determining (1) the mechanisms that make chromatin suitable for condensin action in vivo,(2) the role of condensin at telomeres, and (3) the link between condensin and S phase.
Located in Teams / Chromatin Dynamics in Chromosome Architecture - P. Bernard
Chromatin Dynamics in Chromosome Architecture - P. Bernard
The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The profound reorganisation of long chromatin fibres into rod-shaped chromosomes in mitosis is an iconic example of this structural dynamics. The main goal of our research is to understand the cellular mechanisms that take place at the chromatin level for the assembly of segregation-competent mitotic chromosomes. We use the fission yeast Schizosaccharomyces pombe and human cultured cells as model systems.
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Physical Biology of Chromatin - D. Jost
In close connection with experimental biology, our research addresses generic or specific biological questions on chromatin and gene regulation by developing physical and computational models. Particularly, we focus on the spatio-temporal dynamics of eukaryotic chromosomes. Our research tackles important questions regarding the coupling between 3D structure and functions of chromatin. Our objective is to provide some universal principles driving chromatin folding and regulation, while contextualizing our approaches to fundamental, specific problems of 3D genomics.
Located in Teams
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Located in Teams / Genome mechanics - A. Piazza
Research
Located in Teams / Genome mechanics - A. Piazza