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Chromatin Dynamics in Chromosome Architecture - P. Bernard
The main goal of our research is to understand the mechanisms used by cells to assemble mitotic chromosomes that can be efficiently transmitted throughout cell divisions. We use the fission yeast Schizosaccharomyces pombe as a model organism.
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Alternative splicing and tumoral progression - D. Auboeuf
Our team is interested in the regulation of alternative splicing, the main process allowing to largely increase the functional diversity of proteins coded by a limited number of genes in higher organisms.
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Systems Biology of Decision Making - O. Gandrillon
The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms controlling self-renewal and the alteration of these mechanisms in relation to the onset of cancer.
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Chromatin Dynamics and Chromosome Architecture - P. Bernard
Chromatin Dynamics and Chromosome Architecture - P. BERNARD
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Presentation
Comparative and Integrative Genomics of Organ Development - CIGOGNE - S.Pantalacci/M. Sémon
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Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon
We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs.
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Our research group is interested in the fundamental genetic mechanisms underlying inter-individual phenotypic differences. We wish to better understand why some individuals are more likely than others to develop specific traits.
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The cell is a level of biological organisation that has been poorly explored from an evolutionary perspective. How do cellular mechanisms evolve? What is the extent of possible solutions that have been retained across evolution to achieve basic cellular functions?
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Quantitative regulatory genomics - Mirko Francesconi
Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time to contribute to phenotypic variation.
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Quantitative regulatory genomics - M. Francesconi
Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time to contribute to phenotypic variation.
Located in Teams