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Evolutionary Cell Biology in Nematodes - M. Delattre
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Evolutionary Cell Biology in Nematodes - M. Delattre
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We compare basic cellular functions between closely related species. We ask to what extent the underlying mechanisms have evolved, at the molecular and the biophysical level. We explore which parameters of the system are constraining change or building in innovation.
We use free-living nematodes as a study system because they offer many experimental advantages
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Systems Biology of Decision Making - O. Gandrillon
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The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms controlling self-renewal and the alteration of these mechanisms in relation to the onset of cancer.
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Epithelial differentiation and morphogenesis in Drosophila - M. Grammont
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Epigenetic regulation of cell identity and environmental stress responses - F. Palladino
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We are interested in understanding the role of conserved chromatin marks in the maintenance of germline identity and the response to environmental stress.
To adress these questions, we are using C. elegans as a model organism. We use a combination of genetic, biochemical and genome wide approaches.
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Comparative and Integrative Genomics of Organ Development - CIGOGNE - S.Pantalacci/M. Sémon
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Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon
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We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs.
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Epigenetics and Zygote Formation - B. Loppin
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The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual reproduction in animals. Notably, the transmission of the paternal genome implies unique chromatin reorganization events that take place during spermiogenesis and at fertilization.
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