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Epigenetics and Zygote Formation - B. Loppin
The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual reproduction in animals. Notably, the transmission of the paternal genome implies unique chromatin reorganization events that take place during spermiogenesis and at fertilization.
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The cell is a level of biological organisation that has been poorly explored from an evolutionary perspective. How do cellular mechanisms evolve? What is the extent of possible solutions that have been retained across evolution to achieve basic cellular functions?
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Structure and Interactions of Molecular Biosystems - M. Spichty
We apply atomic-level computer simulations and molecular and cellular biology experiments to gain insights into the dynamic structure of proteins and their interactions in living cells. The main goal is to understand the factors that determine the interaction strength between proteins and how the cell modulates these interactions to regulate biological functions.
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Epigenetic regulation of cell identity and environmental stress responses - F. Palladino
We are interested in understanding the role of conserved chromatin marks in the maintenance of germline identity and the response to environmental stress. To adress these questions, we are using C. elegans as a model organism. We use a combination of genetic, biochemical and genome wide approaches.
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Comparative and Integrative Genomics of Organ Development - CIGOGNE - S.Pantalacci/M. Sémon
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Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon
We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs.
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Epithelial differentiation and morphogenesis in Drosophila - M. Grammont
Epithelia form a vital part of all our tissues and organs. The adhesive properties of these cellular sheets and the ability of their component cells to change shape and/or to move are essential to generate a large number of tissues and organs.
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Systems Biology of Decision Making - O. Gandrillon
The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms controlling self-renewal and the alteration of these mechanisms in relation to the onset of cancer.
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