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Mutations can change cellular proliferation under repeated stress

Molecular Systems Biology publication : Yvert group

Mutations can change cellular proliferation under repeated stress

Cells decide to divide or not according to their environmental context, which changes over time. Many molecular pathways by which cells sense their environment to make this decision are known, especially in powerful model organisms such as the baker's yeast Saccharomyces cerevisiae. However, the dynamical properties of these pathways are poorly characterized. Which genes are critical for decision-making when environmental conditions vary rapidly? In a study published on March 5th 2018 in Molecular Systems Biology, the group of Gaël Yvert  identified hundreds of genes that are essential for the control of yeast cell proliferation when environmental stress is highly dynamic. These findings not only inform on the dynamic properties of environmental sensing but also illustrate how unexpected mutations can become selected in highly dynamic environments.

Genomics of cellular proliferation in periodic environmental fluctuations. Salignon J, Richard M, Fulcrand E, Duplus-Bottin H, Yvert G.

Figure legend : Outline of the genomic screen used in this study: thousands of mutant cells are cultured together and their relative abundance in the population was estimated. B) Results for mutant cells lacking the gene coding for phosphodiesterase Pde2. Relative abundance of cells carrying a defective pde2 gene when they were co-cultured with all other mutants (BAR-seq) or when they were co-cultured with wild-type cells (cytometry).


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