Annuaire
Corentin Claeys Bouuaert Université catholique de Louvain - Belgique
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Le 12/11/2021, de 11:00 à 12:00 |
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| S'adresser à | Equipe Piazza - Salle des Thèses |
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Contact : Aurèle Piazza
The formation of haploid gametes relies on a recombination program that promotes the pairing and accurate segregation of homologous chromosomes prior to the first meiotic division. Meiotic recombination is initiated by the programmed induction of DNA double-strand breaks (DSBs) by a topoisomerase-related protein Spo11, together with nine accessory subunits in yeast. A mechanistic understanding of meiotic DSB formation has long been hampered by difficulties in purifying Spo11 and its essential partners. In the last few years, we have solved this issue, opening avenues for biochemical studies. In this presentation, I will describe our recent work to delineate the structure and function of the meiotic DSB machinery, and their connection with the higher-order organization of meiotic chromosomes.