Annuaire
Dominique Weil - Institute of Biology Paris-Seine, Paris, France.
Importance of the GC content of mRNAs for their storage in P-bodies
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Le 30/10/2020, de 11:00 à 12:00 |
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| S'adresser à | Equipe Ricci, Online |
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Gene expression depends on the balance between RNA synthesis, decay and translation. In eukaryotes, RNAs and their associated proteins can condensate into cytoplasmic membrane-less organelles called P-bodies. Following the purification of P-bodies from human cells, we could show that they are primarily involved in the coordinated storage of poorly translated mRNAs. These mRNAs encode a large variety of proteins, which tend to have regulatory functions. Combining this dataset with various transcriptomic analysis led us to propose an integrative model of post-transcriptional regulation, where the mRNA GC content plays a key role in coordinating a coherent but nevertheless adaptable gene expression program.
Contact : E. Ricci