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Jon Houseley, Babraham Institute, Cambridge

Transcriptionally-stimulated copy number variation as a mechanism for rapid adaptation to challenging environments
When Jan 22, 2021
from 11:00 to 12:00
Contact Name WEBINAR, ONLINE Equipe Palldino
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It is widely thought that purely random mutations form the genetic variation on which natural selection acts. However, mechanistic studies show that interactions between DNA replication and transcription drive highly non-random mutagenic processes. My group is investigating the extent to which cells can harness this transcriptionally-stimulated mutation to accelerate adaptation to challenging environments


We have demonstrated that budding yeast adapt to environmental copper through non-random transcriptionally-stimulated copy number variation (CNV) at the CUP1 locus, and similarly shown that ribosomal DNA CNV is controlled in response to glucose. These events occur as replication forks encounter transcriptionally active loci, and undergo complex repair events dictated by local chromatin structure.


In this seminar I will talk about our studies of mechanisms by which interactions between the replication and transcription machinery produce locus specific non-random CNV events, and discuss how such non-random CNV events can accelerate adaptation.


Contact : F. Palladino