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David GATFIELD - Université de Lausanne, Suisse

Using the circadian clock to uncover mechanisms and functions of post-transcriptional gene expression regulation
When Feb 03, 2023
from 11:00 to 12:00
Contact Name Salle des Thèses - Equipe Ricci
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Most mammalian behaviour and physiology undergoes regular daily variations that are controlled by an internal timing system known as the circadian clock. The molecular basis of circadian timekeeping lies in rhythmic gene expression that is generated through the rhythmic activity of transcription factors, yet it has become clear that additional regulation at the RNA level - in particular RNA stability and translation - makes important contributions as well. Using mice and cells, our lab studies such post-transcriptional mechanisms in the context of the circadian oscillator, which represents an excellent paradigm for differential gene expression (with different physiological states naturally given, just spaced by a few hours) that is amenable to studies all the way from the biochemical to the behavioural level. With our work we wish to make contributions not only to chronobiology, but also use this system to uncover general principles of gene expression regulation, beyond the clock. In this seminar, I will try to cover both lines of research: (1) an ongoing circadian project, on the role of the nonsense-mediated decay (NMD) pathway as a physiological mechanism regulating rhythmic gene expression in mice; and (2) a more fundmental project, on translational pausing.

Contact : Emiliano Ricci