Biologie des systèmes : signalisation et processus cellulaires développementaux
Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon
We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs. Lire la suite
Epigenetic regulation of cell identity and environmental stress responses - F. Palladino
We are interested in how epigenetic regulation contributes to germline function and organismal homeostasis in C. elegans. For this, we combine genetics, genome-wide approaches and microscopy techniques. Lire la suite
Epigénétique et Formation du Zygote - B. Loppin
The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual reproduction in animals. Notably, the transmission of the paternal genome implies unique chromatin reorganization events that take (...) Lire la suite
Epithelial differentiation and morphogenesis in Drosophila - M. Grammont
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Evolution des Processus Cellulaires chez les Nématodes - M. Delattre
We investigate unconventional modes of DNA transmission and genome regulation, exploring their evolutionary origins and consequences. Our primary focus is on nematode species that are lab tractable, enabling integration of (...) Lire la suite
Quantitative regulatory genomics - M. Francesconi
Pourquoi les individus sont-ils différents ? Nous abordons cette question fondamentale en étudiant les sources génétiques et non génétiques de variation phénotypique, à l'aide d'approches de biologie des systèmes de (...) Lire la suite
Systems Biology of Decision Making - O. Gandrillon
The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms (...) Lire la suite