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Biologie des systèmes : signalisation et processus cellulaires développementaux

Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon

We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs. Lire la suite

Epigenetic regulation of cell identity and environmental stress responses - F. Palladino

We are interested in how epigenetic regulation contributes to germline function and organismal homeostasis in C. elegans. For this, we combine genetics, genome-wide approaches and microscopy techniques. Lire la suite

Epigénétique et Formation du Zygote - B. Loppin

The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual reproduction in animals. Notably, the transmission of the paternal genome implies unique chromatin reorganization events that take (...) Lire la suite

Epithelial differentiation and morphogenesis in Drosophila - M. Grammont

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Evolution des Processus Cellulaires chez les Nématodes - M. Delattre

We investigate unconventional modes of DNA transmission and genome regulation, exploring their evolutionary origins and consequences. Our primary focus is on nematode species that are lab tractable, enabling integration of (...) Lire la suite

Quantitative regulatory genomics - M. Francesconi

Pourquoi les individus sont-ils différents ? Nous abordons cette question fondamentale en étudiant les sources génétiques et non génétiques de variation phénotypique, à l'aide d'approches de biologie des systèmes de (...) Lire la suite

Systems Biology of Decision Making - O. Gandrillon

The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms (...) Lire la suite

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