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Polymer Modeling of 3D Epigenome Folding: Application to Drosophila.
Methods Mol Biol, 2301:293-305.
Mechanistic modeling in biology allows to investigate, based on first principles, ifputative hypotheses are compatible with observations and to drive furtherexperimental works. Along this line, polymer modeling has been instrumental in 3Dgenomics to better understand the impact of key mechanisms on the spatial genomeorganization. Here, I describe how polymer-based models can be practically used tostudy the role of epigenome in chromosome folding. I illustrate this methodology inthe context of Drosophila epigenome folding.
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