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The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.
Nat Commun, 11(1):6348.
Long non-coding RNAs are important regulators of biological processes includingimmune responses. The immunoregulatory functions of lncRNAs have been revealedprimarily in murine models with limited understanding of lncRNAs in human immuneresponses. Here, we identify lncRNA LUCAT1 which is upregulated in human myeloidcells stimulated with lipopolysaccharide and other innate immune stimuli. Targeteddeletion of LUCAT1 in myeloid cells increases expression of type I interferonstimulated genes in response to LPS. By contrast, increased LUCAT1 expressionresults in a reduction of the inducible ISG response. In activated cells, LUCAT1 isenriched in the nucleus where it associates with chromatin. Further, LUCAT1 limitstranscription of interferon stimulated genes by interacting with STAT1 in thenucleus. Together, our study highlights the role of the lncRNA LUCAT1 as apost-induction feedback regulator which functions to restrain the immune response inhuman cells.
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