Detrended signal

Sometimes it is possible to use additional data to detrend the signal so that the sliding window strategy as used previously is no longer required to fit the HMM. For example, (4) used data from tiling array on which they hybridized the full DNA (including DNA from nucleosomes and linkers) to remove the probe effect and so to normalize their signal. In that case, one can be interested to either fit the HMM on the entire chromosome without using sliding window, or when nucleosome positions are already known on some regions, to train the HMM on these region and then to use the trained version of the HMM to predict nucleosome positions elsewhere on the genome.

TODO