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Accès aux hétérocycles par catalyse organométallique et photocatalyse visible.

Séminaire du Département de Chimie

 

Mercredi 25 Avril 2018 - 15h45 - Amphi Schrödinger.

Philippe Belmont (Faculté de Pharmacie de Paris, Université Paris Descartes)


 


Photo d'amphitheatre

Accès aux hétérocycles par catalyse organométallique et photocatalyse visible.


CV

Philippe Belmont was born in Paris in 1970, grew up in the French Caribbean and in 1990 moved to Grenoble (France) to study at the University Joseph Fourier, where he obtained in 1996 a PhD in Organic Chemistry under the guidance of Dr. M. Demeunynck and Prof. Jean Lhomme. He then moved successively as a post-doctoral fellow to Case Western Reserve University (Prof. A. J. Pearson, Cleveland, USA) and to the Collège de France (Prof. J.-M. Lehn and Dr. J.-P. Vigneron, Paris, France). In 2000 he joined the group of Prof. M. A. Ciufolini (University of Lyon, France) as a Researcher for the Centre National de la Recherche Scientifique (CNRS). Then, in 2004 he obtained the habilitation diploma and since then has managed a research group investigating organometallic chemistry for the synthesis of heterocyclic compounds, with interest in their biological properties. In 2009 he moved to Paris at the Institut Curie (CNRS section 12 bronze medal in 2009) and became in 2011 Full Professor of Organic Chemistry at the School of Pharmacy of the University Paris Descartes.


Research Summary

We are particularly interested in the use of organometallics (silver, gold, cobalt, ruthenium and rhodium salts) in order to access numerous heterocyclic cores. Part of our work is also devoted to the study of their biological properties, particularly for kinases’ inhibition (development of cyclopenta[c]acridinones exhibiting exquisite biological properties, in collaboration with Dr. L. Meijer). We therefore develop the original synthesis of phthalazines, isoindolinones, isobenzofuranones, isochomenes, quinolines, acridines, dibenzofurans and carbazoles derivatives, using metal-catalyzed cycloisomerization reactions and, in collaboration with Dr. E. Brachet, visible-light photocatalysis.

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