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Biophysics and Development

Personnel du RDP


(33) 4 72 72 88 75

Françoise MONEGER

(33) 4 72 72 89 85

Pradeep DAS

(33) 4 72 72 89 37

Annamaria KISS

(33) 4 72 72 89 37

Simone BOVIO

(33) 4 72 72 87 62

Virginie BATTU

(33) 4 72 72 86 07

Yuchen LONG

(33) 4 72 72 88 25
Postdoc ENS


(33) 4 72 72 38 32
Postdoc ENS

Corentin MOLLIER

(33) 4 72 72 89 37


Doll NM, Bovio S, Gaiti A, Marsollier AC, Chamot S, Moussu S, Widiez T, Ingram GC. "The Endosperm-Derived Embryo Sheath Is an Anti-adhesive Structure that Facilitates Cotyledon Emergence during Germination in Arabidopsis". Current Biology (2020)
PMID: 32155415


Long Y, Boudaoud A "Emergence of robust patterns from local rules during plant development". Current Opinion in Plant Biology 127-137 (2019)
PMID: 30577002

Fruleux A, Boudaoud A. "Modulation of tissue growth heterogeneity by responses to mechanical stress.". Proc Natl Acad Sci U S A 16 1940-1945 (2019)
PMID: 30674660

Aliee M, Boudaoud A. "Patterns of Polar Domains in a Spatiotemporal Model of Interacting Polarities". Phys Rev Lett. 123 (2019)
PMID: 31386491

Miart F, Fournet F, Dubrulle N, Petit E, Demailly H, Dupont L, Zabijak L, Marcelo P, Boudaoud A, Pineau C, Guénin S, Van Wuytswinkel O, Mesnard F, Pageau K. "Cytological Approaches Combined With Chemical Analysis Reveals the Layered Nature of Flax Mucilage.". Front Plant Sci. 10:684 (2019)
PMID: 31293601

Fruleux A, Verger S, Boudaoud A. "Feeling Stressed or Strained? A Biophysical Model for Cell Wall Mechanosensing in Plants". Front Plant Sci. 10:757 (2019)
PMID: 31244875

Davì V, Chevalier L, Guo H, Tanimoto H, Barrett K, Couturier E, Boudaoud A, Minc N. "Systematic mapping of cell wall mechanics in the regulation of cell morphogenesis.". Proc Natl Acad Sci U S A 116 (2019)
PMID: 31235592

Julien JD, Pumir A, Boudaoud A. "Strain- or Stress-Sensing in Mechanochemical Patterning by the Phytohormone Auxin.". Bull Math Biol. 81 (2019)
PMID: 30903593

Bovio S, Long Y, Monéger F. "Use of Atomic Force Microscopy to Measure Mechanical Properties and Turgor Pressure of Plant Cells and Plant Tissues.". J Vis Exp. (2019)
PMID: 31355790

Hamant O, Das P, Burian A. "Time-Lapse Imaging of Developing Shoot Meristems Using A Confocal Laser Scanning Microscope.". Methods Mol Biol. 1992 (2019)
PMID: 31148044

Zhao F, Chen WQ, Sechet J, Martin M, Bovio S, Lionnet C, Long Y, Battu V, Mouille G, Monéger F, Traas J. "Xyloglucans and microtubules synergistically maintain meristem geometry and phyllotaxis". Plant Physiol. (2019)
PMID: 31537749


Fruleux A, Boudaoud A "Modulation of tissue growth heterogeneity by responses to mechanical stress". bioRXiv (2018)

S. Verger, Y. Long, A. Boudaoud & O. Hamant* "A tension-adhesion feedback loop in plant epidermis". eLIFE 7 e34460 (2018)
PMID: 29683428

J.-D. Julien & A. Boudaoud* "Elongation and shape changes in organisms with cell walls: a dialogue between experiments and models". The Cell Surface 1 34–42 (2018)
V. Mirabet*, P. Krupinski, O. Hamant, E.M. Meyerowitz, H. Jönsson & A. Boudaoud.* "The self-organization of plant microtubules inside the cell volume yields their cortical localization, stable alignment, and sensitivity to external cues". PLoS Comput. Biol. 14 e1006011 (2018)
PMID: 29462151

L. Hong#, M. Dumond#, M. Zhu, S. Tsugawa, C.-B. Li, A. Boudaoud, O. Hamant & A.H.K. Roeder* "Heterogeneity and Robustness in Plant Morphogenesis: From Cells to Organs". Annual Reviews of Plant Biology 69 469–495 (2018)
PMID: 29505739

V. Davì, H. Tanimoto, D. Ershov, A. Haupt, H. De Belly, R. Le Borgne, E. Couturier, A. Boudaoud* & Nicolas Minc* "Mechanosensation dynamically coordinates polar growth and cell wall assembly to promote survival". Dev. Cell 45 170–182 (2018)
PMID: 29689193

Amélie Andres-Robin, Mathieu Reymond, Antoine Dupire, Virginie Battu, Nelly Dubrulle, Grégory Mouille, Valérie Lefebvre, Jerome Pelloux, Arezki Boudaoud, Jan Traas, Charles Patrick Scutt, Françoise Monéger "Evidence for the control of Arabidopsis gynoecium morphogenesis by ETTIN via cell wall dynamics". Plant Physiology American Society of Plant Biologists (2018)
PMID: 30237208


P. Durand-Smet, E. Gauquelin, N. Chastrette, A. Boudaoud & A. Asnacios*. "Estimation of turgor pressure through comparison between single plant cell and pressurized shell mechanics. ". Physical Biol 14, 055002 (2017)

S. Tsugawa, N. Hervieux, D. Kierzkowski, A.-L. Routier-Kierzkowska, A. Sapala, O. Hamant, R. S. Smith, A. H. K. Roeder, A. Boudaoud & C.-B. Li*. "Clones of cells switch from reduction to enhancement of size variability in Arabidopsis sepals.". Development. 144 4398-4405 (2017)
PMID: 29183944

J. Chlasta, P. Milani, G. Runel, J.-L. Duteyrat, L. Arias, L.-A. Lamiré, A. Boudaoud & M. Grammont* "Variations in basement membrane mechanics are linked to epithelial morphogenesis". Development 144 4350–4362 (2017)
PMID: 29038305

Hervieux N, Tsugawa S, Fruleux A, Dumond M, Routier-Kierzkowska AL, Komatsuzaki T, Boudaoud A, Larkin JC, Smith RS, Li CB, Hamant O. "Mechanical shielding of rapidly growing cell buffers growth heterogeneity and contributes to organ shape reproducibility.". Curr Biol. 27 3468-3479.e4 (2017)
PMID: 29129534

"Prunet N, W Yang, P Das, EM Meyerowitz and TP...". (2017)
Prunet N, W Yang, P Das, EM Meyerowitz and TP Jack. SUPERMAN prevents class B gene expression and promotes stem cell termination in the fourth whorl of Arabidopsis thaliana flowers. PNAS 114: 7166 (2017).

A.Kiss, T.Moreau, V. Mirabet, C. I.Calugaru, A. Boudaoud, P. Das "Segmentation of 3D images of plant tissues at multiple scales using the level set method". Plant Methods 13 (2017)
PMID: 29296118


Bar-Sinai Y, Julien JD, Sharon E, Armon S, Nakayama N, Adda-Bedia M, Boudaoud A. "Mechanical Stress Induces Remodeling of Vascular Networks in Growing Leaves.". PLoS Comput Biol. 12 (2016)
PMID: 27074136

N. Hervieux, M. Dumond, A. Sapala, A.-L. Routier-Kierzkowska, D. Kierzkowski, A. Roeder, R.S. Smith, A. Boudaoud* & O. Hamant* "A mechanical feedback restricts sepal growth and shape in Arabidopsis". Curr Biol. 26 1019–1028 (2016)
PMID: 27151660

Tsugawa S, Hervieux N, Hamant O, Boudaoud A, Smith RS, Li CB, Komatsuzaki T. "Extracting subcellular fibrillar alignment with error estimation: Application to microtubules.". Biophys J. 110 1836-1844 (2016)
PMID: 27119643

Hong L, Dumond M, Tsugawa S, Sapala A, Routier-Kierzkowska AL, Zhou Y, Chen C, Kiss A, Zhu M, Hamant O, Smith RS, Komatsuzaki T, Li CB, Boudaoud A, Roeder AH. "Variable cell growth yields reproducible organ development through spatiotemporal averaging
.". Dev Cell. 38 15-32 (2016)
PMID: 27404356

Fourquin C, Beauzamy L, Chamot S, Creff A, Goodrich J, Boudaoud A, Ingram G. "Mechanical stress mediated by both endosperm softening and embryo growth underlies endosperm elimination in Arabidopsis seeds.". Development. 143 3300-5 (2016)
PMID: 27287798

Louveaux M, Rochette S, Beauzamy L, Boudaoud A, Hamant O. "The impact of mechanical compression on cortical microtubules in Arabidopsis: a quantitative pipeline.". Plant J. 88 328-342 (2016)
PMID: 27482848

E. Biot+, M. Cortizo+, J. Burguet+*, A. Kiss+, M. Oughou, A. Maugarny-Calès, B. Gonçalves, B. Adroher, P. Andrey, A. Boudaoud* & P. Laufs*. "Multiscale quantification of morphodynamics: MorphoLeaf software for 2D shape analysis. ". Development 143 3417-28 (2016)
PMID: 27387872

"F. Kateryna, B. Landrein & O. Hamant*....". (2016)
F. Kateryna, B. Landrein & O. Hamant*. Interplay between miRNA regulation and mechanical stress for CUC gene expression at the shoot apical meristem. Plant Signal. Behav. 11, e1127497 (2016).

Alim K, Armon S, Shraiman BI, Boudaoud A. "Leaf growth is conformal.". Phys Biol. 13 (2016)
PMID: 27597439

R. Malgat, F. Faure & A. Boudaoud* "A mechanical model to interpret cell-scale indentation experiments on plant tissues in terms of cell wall elasticity and turgor pressure.". Front Plant Sci. 7 1351 (2016)
PMID: 27656191

Ezquer I, Mizzotti C, Nguema-Ona E, Gotté M, Beauzamy L, Viana VE, Dubrulle N, Costa de Oliveira A, Caporali E, Koroney AS, Boudaoud A, Driouich A, Colombo L. "The developmental regulator STK controls the structure and mechanical properties of the Arabidopsis seed coat.". Plant Cell. 28 2478-2492 (2016)
PMID: 27624758

Beauzamy L, Fourquin C, Dubrulle N, Boursiac Y, Boudaoud A, Ingram G. "Endosperm turgor pressure decreases during early Arabidopsis seed development.". Development. 143 3295-9 (2016)
PMID: 27287811

Louveaux M, Julien JD, Mirabet V, Boudaoud A, Hamant O. "Cell division plane orientation based on tensile stress in Arabidopsis thaliana.". Proc Natl Acad Sci U S A. 113 E4294-303 (2016)
PMID: 27436908


"J. Chopin*, A. Boudaoud & M. Adda-Bedia....". (2015)
J. Chopin*, A. Boudaoud & M. Adda-Bedia. Morphology and dynamics of a crack front propagating in a model disordered material. J. Mech. Phys. Solids 74, 38–48 (2015).

Boudon F, Chopard J, Ali O, Gilles B, Hamant O, Boudaoud A, Traas J, Godin C. "A computational framework for 3D mechanical modeling of plant morphogenesis with cellular resolution.". PLoS Comput Biol. 11 e1003950 (2015)
PMID: 25569615

Beauzamy L, Derr J, Boudaoud A. "Quantifying Hydrostatic Pressure in Plant Cells by using Indentation with an Atomic Force Microscope". Biophys J. 108 2448-2456 (2015)
PMID: 25992723

Beauzamy L, Louveaux M, Hamant O, Boudaoud A. "Mechanically, the shoot apical meristem of Arabidopsis behaves like a shell inflated by a pressure of about 1 MPa.". Front Plant Sci. 6 (2015)
PMID: 27074136

Barbier de Reuille P, Routier-Kierzkowska AL, Kierzkowski D, Bassel GW, Schüpbach T, Tauriello G, Bajpai N, Strauss S, Weber A, Kiss A, Burian A, Hofhuis H, Sapala A, Lipowczan M, Heimlicher MB, Robinson S, Bayer EM, Basler K, Koumoutsakos P, Roeder AH, Aegerter-Wilmsen T, Nakayama N, Tsiantis M, Hay A, Kwiatkowska D, Xenarios I, Kuhlemeier C, Smith RS. "MorphoGraphX: A platform for quantifying morphogenesis in 4D.". Elife 4 (2015)
PMID: 25946108

"Klein-Cosson C, Chambrier P, Rogowsky PM,...". (2015)
Klein-Cosson C, Chambrier P, Rogowsky PM, Vernoud V.
Regulation of a maize HD-ZIP IV transcription factor by a non-conventional RDR2-dependent small RNA.
Plant J. 2015 [PMID:25619590]

Landrein B, Refahi Y, Besnard F, Hervieux N, Mirabet V, Boudaoud A, Vernoux T, Hamant O. "Meristem size contributes to the robustness of phyllotaxis in Arabidopsis.". Journal of Experimental Botany 66 1317-24 (2015)
PMID: 25504644

Landrein B, Kiss A, Sassi M, Chauvet A, Das P, Cortizo M, Laufs P, Takeda S, Aida M, Traas J, Vernoux T, Boudaoud A, Hamant O. "Mechanical stress contributes to the expression of the STM homeobox gene in Arabidopsis shoot meristems.". Elife 4 (2015)
PMID: 26623515
Featured in F1000 (2★)


"Ali, O., Mirabet, V., Godin, C., Traas, J....". (2014)
Ali, O., Mirabet, V., Godin, C., Traas, J. (2014). Physical Models of Plant Development. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY 30, 59-78.

"Collaudin, S. and Mirabet, V. (2014). Models...". (2014)
Collaudin, S. and Mirabet, V. (2014). Models to reconcile plant science and stochasticity. FRONTIERS IN PLANT SCIENCE 5, 643.

Beauzamy L, Nakayama N, Boudaoud A. "Flowers under pressure: ins and outs of turgor regulation in development.". Ann Bot. 114 1517-33 (2014)
PMID: 25288632

Durand-Smet P, Chastrette N, Guiroy A, Richert A, Berne-Dedieu A, Szecsi J, Boudaoud A, Frachisse JM, Bendahmane M, Hamant O, Asnacios A. "A comparative mechanical analysis of plant and animal cells reveals convergence across kingdoms". Biophys J. 107 2237-44 (2014)
PMID: 25418292

Oftadeh R, Haghpanah B, Vella D, Boudaoud A, Vaziri A. "Optimal Fractal-like Hierarchical Honeycombs.". Phys Rev Lett. 113 104301 (2014)
PMID: 25238362

"Sassi M, Ali O, Boudon F, Cloarec G, Abad U,...". (2014)
Sassi M, Ali O, Boudon F, Cloarec G, Abad U, Cellier C, Milani P, Chen X, Friml J, Vernoux T, Godin C, Hamant O & Traas J (2014) An auxin-mediated shift towards growth isotropy promotes organ formation at the shoot apical meristem in Arabidopsis. CURRENT BIOLOGY 24:2335-2342

"Rozier F, Mirabet V, Vernoux T & Das P (2014)...". (2014)
Rozier F, Mirabet V, Vernoux T & Das P (2014) Analysis of 3-D gene expression patterns in plants using whole-mount RNA in situ hybridization. NATURE PROTOCOLS 9: 2464-2475

Milani P, Mirabet V, Cellier C, Rozier F, Hamant O, Das P, Boudaoud A. "Matching patterns of gene expression to mechanical stiffness at cell resolution through quantitative tandem epifluorescence and nanoindentation.". Plant Physiol. 165 1399-1408 (2014)
PMID: 24924426

Sampathkumar A, Krupinski P, Wightman R, Milani P, Berquand A, Boudaoud A, Hamant O, Jönsson H, Meyerowitz EM. "Sub-cellular and supra-cellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells". Elife. 3 e01967 (2014)
PMID: 24740969

Bonazzi D, Julien JD, Romao M, Seddiki R, Piel M, Boudaoud A, Minc N. "Symmetry breaking in spore germination relies on an interplay between polar cap stability and spore wall mechanics. ". Dev Cell. 46 388 (2014)
PMID: 24636258

Ebrahimi H, Ajdari A, Vella D, Boudaoud A, Vaziri A. "Anisotropic Blistering Instability of Highly Ellipsoidal Shells.". Phys Rev Lett. 112 094302 (2014)
PMID: 24655258

"Bayart, E., Boudaoud, A., and Adda-Bedia, M....". (2014)
Bayart, E., Boudaoud, A., and Adda-Bedia, M. (2014). Tuning the ordered states of folded rods by isotropic confinement. PHYSICAL REVIEW E 89, 012407.

Boudaoud A, Burian A, Borowska-Wykręt D, Uyttewaal M, Wrzalik R, Kwiatkowska D, Hamant O. "FibrilTool, an ImageJ plugin to quantify fibrillar structures in raw microscopy images.". Nat Protoc. 9 457-63 (2014)
PMID: 24481272

"Hamant, O., Das, P. Burian, A. (2014)....". (2014)
Hamant, O., Das, P. Burian, A. (2014). Time-lapse imaging of developing meristems using confocal laser scanning microscope. METHODS IN MOLECULAR BIOLOGY 1080, 111.

"Landrein B. and Vernoux T. (2014) Auxin,...". (2014)
Landrein B. and Vernoux T. (2014) Auxin, chief architect of the shoot Apex. In Auxin and its role in plant development, Zazimalova et al., eds (Springer-Verlag Wien), pp. 191-212

"Widiez T, Symeonidi A, Luo C, Lam E, Lawton...". (2014)
Widiez T, Symeonidi A, Luo C, Lam E, Lawton M, Rensing SA
The chromatin landscape of the moss Physcomitrella patens and its dynamics during development and drought stress. Plant Journal 2014 [PMID: 24779858]

Besnard, F., Refahi, Y., Morin, V., Marteaux, B., Brunoud, G., Chambrier, P., Rozier F., Mirabet V., Legrand J., Lainé S., Thévenon E., Farcot E., Cellier C., Das P., Bishopp A., Dumas R., Parcy F., Helariutta Y., Boudaoud A., Godin C., Traas J., Guédon Y., & Vernoux, T. "Cytokinin signalling inhibitory fields provide robustness to phyllotaxis.". Nature. 505 417-21 (2014)
PMID: 24336201
Featured in F1000 (2★)


"Landrein B, Hamant O. How mechanical stress...". (2013)
Landrein B, Hamant O. How mechanical stress controls microtubule behavior and morphogenesis in plants: history, experiments and revisited theories. PLANT J. 75, 324-38

"Louveaux, M. and Hamant, O. (2013). The...". (2013)
Louveaux, M. and Hamant, O. (2013). The mechanics behind cell division. CURRENT OPINION IN PLANT BIOLOGY 16, 774.

"Hamant, O. (2013). Cell Biology: Cytoskeleton...". (2013)
Hamant, O. (2013). Cell Biology: Cytoskeleton Network Topology Feeds Back on Its Regulation. CURRENT BIOLOGY 23, R963.

"Hamant, O. (2013). Widespread mechanosensing...". (2013)
Hamant, O. (2013). Widespread mechanosensing controls the structure behind the architecture in plants. CURRENT OPINION IN PLANT BIOLOGY 16, 654.

"de Bossoreille de Ribou, S., Douam, F.,...". (2013)
de Bossoreille de Ribou, S., Douam, F., Hamant, O., Frohlich, M.W. and Negrutiu I. (2013). Plant science and agricultural productivity: why are we hitting the yield ceiling? PLANT SCIENCE 210, 159.

"Hamant, O. (2013). Integrative Cell Biology;...". (2013)
Hamant, O. (2013). Integrative Cell Biology; Katanin at the Crossroads. CURRENT BIOLOGY 23, R206.

"Burian, A., Ludynia, M., Uyttewaal, M.,...". (2013)
Burian, A., Ludynia, M., Uyttewaal, M., Traas, J., Boudaoud, A., Hamant, O. and Kwiatkowska, D. (2013). A correlative microscopy approach relates microtubule behaviour, local organ geometry, and cell growth at the Arabidopsis shoot apical meristem. JOURNAL OF EXPERIMENTAL BOTANY 64, 5753.

"Milani, P., Braybrook, S.A. and Boudaoud, A....". (2013)
Milani, P., Braybrook, S.A. and Boudaoud, A. (2013). Shrinking the hammer: micromechanical approaches to morphogenesis. JOURNAL OF EXPERIMENTAL BOTANY 64, 4651.

"O’Maoileidigh, D.S., Wuest, S.E., Rae, L.,...". (2013)
O’Maoileidigh, D.S., Wuest, S.E., Rae, L., Raganelli, A., Ryan, P.T., Kwasniewska, K., Das, P., Lohan, A.J., Loftus, B., Graciet, E., Wellmer, F. (2013). Control of Reproductive Floral Organ Identity Specification in Arabidopsis by the C Function Regulator AGAMOUS. PLANT CELL 25, 2482.

"Landrein, B., Lathe, R., Bringmann, M.,...". (2013)
Landrein, B., Lathe, R., Bringmann, M., Vouillot, C., Ivakov, A., Boudaoud, A., Persson, S., and Hamant, O. (2013). Impaired Cellulose Synthase Guidance Leads to Stem Torsion and Twists Phyllotactic Patterns in Arabidopsis. CURRENT BILOGY 23, 895.

"Deboeuf, S., Katzav, E., Boudaoud, A., Bonn,...". (2013)
Deboeuf, S., Katzav, E., Boudaoud, A., Bonn, D. and Adda-Bedia, M. (2013). Comparative Study of Crumpling and Folding of Thin Sheets. PHYSICAL REVIEW LETTERS 110, 104301.


"Bringmann M, Landrein B, Schudoma C, Hamant...". (2012)
Bringmann M, Landrein B, Schudoma C, Hamant O, Hauser MT, Persson S. (2012) Cracking the elusive alignment hypothesis: the microtubule-cellulose synthase nexus unraveled. TRENDS PLANT SCI. 17, 666-74

"Vella, D., Ajdari, A., Vaziri, A. and...". (2012)
Vella, D., Ajdari, A., Vaziri, A. and Boudaoud, A. (2012). Indentation of ellipsoidal and cylindrical elastic shells. PHYSICAL REVIEW LETTERS 109, 144302.
Asnacios, A., Hamant, O. (2012). The mechanics behind cell polarity. TRENDS IN CELL BIOLOGY 22, 584.

"Alim, K., Hamant, O. and Boudaoud, A. (2012)....". (2012)
Alim, K., Hamant, O. and Boudaoud, A. (2012). Regulatory role of cell division rules on tissue growth heterogeneity. FRONTIERS IN PLANT SCIENCES 3,174.

"Proctor, S.A., Minc, N., Boudaoud, A. and...". (2012)
Proctor, S.A., Minc, N., Boudaoud, A. and Chang, F. (2012). Contributions of Turgor Pressure, the Contractile Ring, and Septum Assembly to Forces in Cytokinesis in Fission Yeast. CURRENT BIOLOGY 22, 1601.

"Nakayama, N., Smith, R.S., Mandel,T.,...". (2012)
Nakayama, N., Smith, R.S., Mandel,T., Robinson, S. , Kimura, S. , Boudaoud, A. and Kuhlemeier, C. (2012). Mechanical regulation of auxin-mediated growth. CURRENT BIOLOGY 22, 1468.

"Uyttewaal, M., Burian, A., Alim, K., Landrein,". (2012)
Uyttewaal, M., Burian, A., Alim, K., Landrein, B., Borowska-Wykret, D., Dedieu, A., Peaucelle, A., Ludynia, M., Traas, J., Boudaoud, A., Kwiatkowska, D. and Hamant, O. (2012) Mechanical Stress Acts via Katanin to Amplify Differences in Growth Rate between Adjacent Cells in Arabidopsis. CELL 149, 439.

"Uyttewaal, M., Burian, A., Alim, K., Landrein,". (2012)
Uyttewaal, M., Burian, A., Alim, K., Landrein, B., Borowska-Wykret, D., Dedieu, A., Peaucelle, A., Ludynia, M., Traas, J., Boudaoud, A., Kwiatkowska, D. and Hamant, O. (2012) Mechanical Stress Acts via Katanin to Amplify Differences in Growth Rate between Adjacent Cells in Arabidopsis. CELL 149, 439.

"Vella, D., Ajdari, A., Vaziri, A. and...". (2012)
Vella, D., Ajdari, A., Vaziri, A. and Boudaoud, A. (2012). The indentation of pressurized elastic shells: from polymeric capsules to yeast cells. JOURNAL OF THE ROYAL SOCIETY INTERFACE 9, 448.

"Mirabet, V., Besnard, F., Vernoux and T.,...". (2012)
Mirabet, V., Besnard, F., Vernoux and T., Boudaoud, A. (2012). Noise and robustness in phyllotaxis. PLOS COMPUTATIONAL BIOLOGY 8,e1002389.


"Hamant O, Meyerowitz EM, Traas J. (2011) Is...". (2011)
Hamant O, Meyerowitz EM, Traas J. (2011) Is cell polarity under mechanical control in plants? Plant Signal Behav. Jan 1;6(1)

"Hasson A, Plessis A, Blein T, Adroher B,...". (2011)
Hasson A, Plessis A, Blein T, Adroher B, Grigg S, Tsiantis M, Boudaoud A, Damerval C, Laufs P. (2011) Evolution and Diverse Roles of the CUP-SHAPED COTYLEDON Genes in Arabidopsis Leaf Development. Plant Cell 23(1):54-68.

"Vernoux T, Brunoud G, Farcot E, Morin V, Van...". (2011)
Vernoux T, Brunoud G, Farcot E, Morin V, Van den Daele H, Legrand J, Oliva M, Das P, Larrieu A, Wells D, Guédon Y, Armitage L, Picard F, Guyomarc’h S, Cellier C, Parry G, Koumproglou R, Doonan JH, Estelle M, Godin C, Kepinski S, Bennett M, De Veylder L, Traas J (2011) The auxin signalling network translates dynamic input into robust patterning at the shoot apex. Mol Syst Biol. 7:508.

"Mirabet V, Das P, Boudaoud A, Hamant O....". (2011)
Mirabet V, Das P, Boudaoud A, Hamant O. (2011) The role of mechanical forces in plant morphogenesis. Annu Rev Plant Biol. 62:365-85.

"Milani P, Gholamirad M, Traas J, Arnéodo A,...". (2011)
Milani P, Gholamirad M, Traas J, Arnéodo A, Boudaoud A, Argoul F, Hamant O.
(2011) In vivo analysis of local wall stiffness at the shoot apical meristem in Arabidopsis using atomic force microscopy. Plant J. 67(6):1116-23.

"Bayart E, Boudaoud A, Adda-Bedia M. (2011)...". (2011)
Bayart E, Boudaoud A, Adda-Bedia M. (2011) Finite-distance singularities in the tearing of thin sheets. Phys Rev Lett. 106(19):194301.

"Romanel E, Das P, Amasino RM, Traas J,...". (2011)
Romanel E, Das P, Amasino RM, Traas J, Meyerowitz E, Alves-Ferreira M. (2011) Reproductive Meristem22 is a unique marker for the early stages of stamen development. Int J Dev Biol. 55(6):657-64.

"Chopin J, Prevost A, Boudaoud A, Adda-Bedia...". (2011)
Chopin J, Prevost A, Boudaoud A, Adda-Bedia M. (2011) Crack Front Dynamics across a Single Heterogeneity. Phys Rev Lett. 107(14):144301.

"Vella D, Ajdari A, Vaziri A, Boudaoud A....". (2011)
Vella D, Ajdari A, Vaziri A, Boudaoud A. (2011) Wrinkling of pressurized elastic shells. (2011) Phys Rev Lett. 107(17):174301.

"Besnard F, Vernoux T, Hamant O. (2011)...". (2011)
Besnard F, Vernoux T, Hamant O. (2011) Organogenesis from stem cells in planta: multiple feedback loops integrating molecular and mechanical signals. Cell Mol Life Sci. 2011 Sep;68(17):2885-906.

"Seizilles G, Bayart E, Adda-Bedia M, Boudaoud...". (2011)
Seizilles G, Bayart E, Adda-Bedia M, Boudaoud A. (2011) Bending waves in crumpled sheets. Phys Rev E Stat Nonlin Soft Matter Phys. 84(6-2):065602.

La Rota C, Chopard J, Das P, Paindavoine S, Rozier F, Farcot E, Godin C, Traas J, Monéger F "A data-driven integrative model of sepal primordium polarity in Arabidopsis". Plant Cell 23 4318-33 (2011)
La Rota C, Chopard J, Das P, Paindavoine S, Rozier F, Farcot E, Godin C, Traas J, Monéger F. (2011) A data-driven integrative model of sepal primordium polarity in Arabidopsis. Plant Cell 23(12):4318-33.


"Hamant O, Traas J (2010) The mechanics behind...". (2010)
Hamant O, Traas J (2010) The mechanics behind plant development – Tansley review. New Phytol.185(2):369-85.

"Hamant O, Pautot V. (2010) Plant development:...". (2010)
Hamant O, Pautot V. (2010) Plant development: a TALE story. C R Biol. 333(4):371-81.

"Fernandez R, Das P, Mirabet V, Moscardi E,...". (2010)
Fernandez R, Das P, Mirabet V, Moscardi E, Traas J, Verdeil JL, Malandain G, Godin C. (2010) Imaging plant growth in 4D: robust tissue reconstruction and lineaging at cell resolution. Nat Methods. 7(7):547-53.

"Boudaoud A. (2010) An introduction to the...". (2010)
Boudaoud A. (2010) An introduction to the mechanics of morphogenesis for plant biologists. Trends Plant Sci. 15(6):353-60.

"Cadot O, Touzé C, Boudaoud A. (2010) Linear...". (2010)
Cadot O, Touzé C, Boudaoud A. (2010) Linear versus nonlinear response of a forced wave turbulence system. Phys Rev E Stat Nonlin Soft Matter Phys. 82(4 Pt 2):046211.

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Heisler MG, Hamant O, Krupinski P, Uyttewaal M, Ohno C, Jönsson H, Traas J, Meyerowitz EM. (2010) Alignment between PIN1 polarity and microtubule orientation in the shoot apical meristem reveals a tight coupling between morphogenesis and auxin transport. PLoS Biol. 8(10):e1000516.

Fernandez R, Das P, Mirabet V, Moscardi E, Traas J, Verdeil JL, Malandain G, Godin C. "Imaging plant growth in 4D : robust tissue reconstruction and lineaging at cell resolution.". Nat Methods. 7 547-53 (2010)


"Das, P., Toshiro Ito, Frank Wellmer, Teva...". (2009)
Das, P., Toshiro Ito, Frank Wellmer, Teva Vernoux, Annick Dedieu, Jan Traas, Elliot M. Meyerowitz (2009). Floral stem cell termination involves the direct regulation of AGAMOUS by PERIANTHIA. Development 136, 1605-1611

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Corson F, Hamant O, Bohn S, Traas J, Boudaoud A, Couder Y (2009). Turning a plant tissue into a living cell froth through isotropic growth. Proc Natl Acad Sci USA 106:8453-8458

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"Hamant O., Heisler MG., Jonsson H., Krupinski...". (2008)
Hamant O., Heisler MG., Jonsson H., Krupinski P., Uyttewaal M., Bokov P., Corson F., Sahlin P., Boudaoud A., Meyerowitz EM., Couder Y., Traas J. (2008) Developmental patterning by mechanical signals in Arabidopsis. Science 322 (5908), 1650-1655

Minc N, Boudaoud A, Chang F. "Mechanical Forces of Fission Yeast Growth.". Curr Biol. 24 1436
PMID: 28903054

We study morphogenesis in plants, notably at the shoot apex of Arabidopsis. We focus on robustness of morphogenesis, by analyzing cellular variability and exploring mechanisms that enhance or buffer such variability. To do so, we combine approaches from molecular biology, live imaging, biophysics, data analysis, and modeling. We address these questions and use these approaches in four main topics:
- Mechanics of morphogenesis
- Floral Growth Patterns
- Gene Regulatory Networks
- Modelling Plant Morphogenesis

Useful tools

Mechanics of Morphogenesis

Leader : Arezki Boudaoud

Morphogenesis is the remarkable process by which a developing organism acquires its shape. While molecular and genetic studies have been highly successful in explaining the cellular basis of development and the role of biochemical gradients in coordinating cell fate, understanding morphogenesis remains a central challenge for both developmental biology and biophysics. Indeed, shape is imposed by structural elements, so that an investigation of morphogenesis must address how these elements are controlled at the cell level, and how the mechanical properties of these elements lead to specific growth patterns. Using plants as model systems, we tackle the following questions. (i) Does the genetic and molecular identity of a cell correspond to a mechanical identity. (ii) Do the mechanical properties of the different cell domains predict shape changes. (iii) How does the intrinsic stochasticity of cell mechanics and cell growth lead to reproducible shapes?

Floral Growth Patterns

Leader : Pradeep Das

The emergence of stereotypical shapes and sizes of tissues and organs requires the coordinated regulation of very specific growth patterns across space and time during development. We seek to gain a clear understanding of how the underlying molecular, genetic and physical events govern growth. The most obvious way to measure and describe growth is at the cellular level. Over the last several years, we have developed a software pipeline to computationally track the growth of Arabidopsis flowers at cell resolution and in 4 dimensions (space and time; Fernandez et al., Nature Methods, 2010). We are now in the process of using segmented time course data to statistically analyse floral growth leading up to the first morphogenetic events. Naturally, these patterns are a result of the genetic and mechanical events occurring during development. To this end, we are also examining the link between growth and patterning, and between patterning and mechanics.

Gene Regulatory Networks

Leader : Françoise Monéger

We also perform modeling on gene regulatory networks and develop approaches aiming at integrating different types of data (expression patterns, direct interactions, genetic interactions) in an integrative coherent model. More recently, we focused on the cell wall and on the enzymes involved in cell wall remodeling in order to understand how molecular networks and transcription factors in particular control flower morphogenesis. Our project aims at identifying among 30 transcription factors expressed in the flower, the target genes encoding protein involved in cell wall and try to understand how the regulation of the expression of these genes leads to the control of the flower shapes.

Modelling Plant Morphogenesis

Leader : Annamaria Kiss

In order to be able to model the emergence of an organ’s shape, it is essential to begin with the analysis of data in connection with morphogenesis. Therefore we develop tools for image segmentation (level set, MARS on Openalea) and for data analysis (plugin on MorphoGraphX) and specifically, we carry out the quantitative and statistical analyses of serial images of developing organs, such as leaves, flowers or meristems. In parallel, we are also studying mechanical models of plant tissue. The goal is first to infer mechanical properties from images, and then, using these properties we are seeking to reproduce by modelling the emergence of forms at the tissular level.

Articles in this section

  • Tools

    , by yfesseli

    Images Fiji - Inkscape - rudiments, basics, advanced, other tutorials... Gimp -,, Plant Illustrations- a collection of illustrations and pictures of plants, roots, shoots, inflorescences,
    Statistics (...)

  • Useful links

    , by yfesseli

    Tools developed in the team on the Forge of the CBP
    A collection of general software
    ENS useful IT information
    Le Wiki du RIB (service informatique du RDP/LBMC/CIRI)
    How to make figures and presentations that are friendly to Colorblind people
    Resident permit for (...)

  • Publications

    , by yfesseli

    2017 Kiss, A.; Moreau, T.; Mirabet, V.; Calugaru, C. I.; Boudaoud, A. & Das, P. Segmentation of 3D images of plant tissues at multiple scales using the level set method. Plant Methods, 13, 114 ( 2017), Prunet N, W Yang, P Das, EM Meyerowitz and TP (...)