Curriculum vitæ

Family name, First name : Caillaud Marie-Cécile
Researcher unique identifiers : ORCID : 0000-0002-0348-7024
Researcher ID : G-9320-2018
Date of birth : 14/10/1982
Nationality : French

URL for web site : Cell Signalling and Endocytosis

Education

2019 Habilitation à Diriger la Recherche (ENS Lyon, FR)

2005-2009 PhD in Molecular and Cellular Biology (University of Nice Sophia-Antipolis, FR) supervised by Dr Pierre ABAD (Pierre.Abad@sophia.inra.fr).

2003-2005 Master of “Biology of Adaptations and Interactions” (with distinction)

Master of “Ecology, Evolution and Genome Plasticity” (with distinction)
University of Nice Sophia-Antipolis, FR.

Current position

Since 2023 Senior group leader “Cell division and membrane lipids” at the RDP.

Previous position

2017-2022 Junior group leader “Cell division and membrane lipids” at the RDP.
2014-2016 “Researcher, CRCN CNRS” (Permanent Researcher Position)
Laboratoire de Reproduction et Développement des Plantes, ENS Lyon

2009-2013 Postdoctoral Research Fellow with Prof. Jonathan Jones (jonathan.jones@tsl.ac.uk) at The Sainsbury Laboratory, Norwich (UK).

Fellowships, Fundings, and Awards

2005-2009 MENRT PhD Scholarship Salary
2009-2010 Long Term EMBO Fellowship (ALTF 614-2009)‏ Salary
2010-2012 Long Term Marie Curie Fellowship (FP7-PEOPLE-2009-IEF)‏ 170K₤
2012-2015 Associated Investigator of UK BBSRC Grant (BB/K009176/1) 600K₤
2016-2018 Seed Fund ENS LYON-2016 28K€
2017-2021 Junior Investigator grant (ANR-16-CE13-0021) 300K€
06/2019 Interview for ERC Starting Grant (ranked A, not funded)
2020-2022 Seed Fund ENS LYON-2019 35K€
2021-2025 Associated Investigator of PlantScape (ANR-20-CE13-0026-02) 500K€
2022-2026 Associated Investigator of DivCON (ANR-21-CE13-0016-03) 510K€
2022 Euro-BioImaging User Access Fund 2,5K€
2022-2026 Associated Investigator of ANR/DFG DivFUSE (ANR-22-CE92-0038-02) 709K€

Supervision and Teaching activities

2005-2009 Teaching position at the University of Nice Sophia-Antipolis during my PhD. Level : Bachelor and Master. (64 h/year, during 4 years).

2018 Practical in imaging : “From samples to quantification” at ENS Lyon, FR Level : Master Advanced Course (36 h)

2019 Seminar : “Role of the Phosphoinositides in Plant Cell Division” at the Máster Oficial en Biotecnología Avanzada, Malaga, SP ? Level : Master Advanced Course (1 h)

PhD committee Sophie Piquerez, UEA Norwich, UK ; Alvaro Montiel Jorda, University of Toulouse, FR ; Mathilde Simon, Nathanaël Jacquier, Estefania Pavesi, ENS LYON, FR

BSc Internship Emilie Andrio, UNSA, FR ; Lucas Courgeon, ENS LYON, FR

Master Mehdi Doumane, ENS LYON, FR ; Alexis Lebecq, UNSA, FR ; Amélie Bauer, University of Lyon 1, FR ; Elsa Gascon, INSA Lyon, FR

PhD Thesis Mehdi Doumane, ENS LYON, FR ; Alexis Lebecq ENS LYON, FR

Reviewing activities

Since 2014 Reviewer PUBLONS
Since 2014 Scientific Evaluation, Labex Saclay Plant Science (FR), Croatian Science Foundation

Editorial activities

2014-2015 Editor for special edition in “Plant Cell Division” for MiMB, Springer
2020-2021 Editor for the second edition of Plant Cell Division for MiMB, Springer

National Responsibilities

2021 Member of the Section 23 of the CNRS (Biologie végétale intégrative)

Local Responsibilities

2015 - Health and Safety Officer
2021 - Referent CNRS for the psychosocial risk

Patents

– Favery, B., Abad P., Caillaud, M.C. (2010) US 20110030095 A1 "Method for increasing the resistance of a plant to endoparasitic nematodes".
– Favery, B., Abad P., Caillaud, M.C. (2008) Procédé pour augmenter la résistance d’une plante aux nématodes endoparasites EP1992699, Munich (GER) : European Patent Office. 41 p.

Oral communications

Invited talks :
(2023) Gordon Conference on plant lipids (Galveston, USA)
(2023) INUPRAG meeting on Plant Integrative Biology (Umeå, Sweden)
(2022) 25th International Symposium on Plant Lipids, Grenoble, (France)
(2022) 4th Jacques Monod Conference on ‘Molecular basis for membrane remodeling and organization’ (France) May 10-15 2022
(2020) INUPRAG-BAICTMD meeting (canceled)
(2019) 12th PhD School Plant Development Retzbach (Germany)
(2018) European Plant Cytoskeletal Club 2018, Prague (CR)
(2015) International meeting of the GS of Cell Biology (Germany)
(2013) Effectome meeting, Montpellier (France).
(2013) Fungal Genomic conference, Asilomar (USA).
Selected talks : (2018) Plant Endocytosis Workshop, Wiston House, (UK)
(2012) ICAR, Vienna (Austria)
(2008) COST Action 872 ; 2nd Annual Meeting, Postojna (Slovenia).
(2007) Molecular Plant-Microbe Interactions, Sorrento (Italie).
Invited lectures : (2020) IBIP Montpellier (FR) ; Host : Alexandre Martinière
(2019) INRAe Versailles (FR) ; Host : Martine Pastuglia

Career breaks

• 15/10/2013 to 01/10/2014 Maternity leave
• 15/09/2016 to 15/05/2017 Maternity leave

PUBLICATIONS

• Corresponding author* (peer-reviewed)

Lebecq. A, C. Goldy, A. Fangain, E. Gascon, K. Belcram, M. Pastuglia, D. Bouchez, M.-C. Caillaud* (2023). The phosphoinositide signature guides the final step of plant cytokinesis. Science advances

Lebecq A., M. Doumane, A. Fangain, V. Bayle, J. Xuan Leong, F. Rozier, M. Marques-Bueno, L. Armengot, R. Boisseau, M. Simon, M. Franz-Wachtel, B. Macek, S. Ustun, Y. Jaillais*, M.-C. Caillaud* (2022) “The Arabidopsis SAC9 Enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the Plasma Membrane” eLife

Lebecq, A., A. Fangain, A. Boussaroque and M.-C. Caillaud* (2022). "Dynamic Apical-Basal Enrichment of the F-Actin during Cytokinesis in Arabidopsis Cells Embedded in their Tissues." Quantitative Plant Biology

Doumane, M., A. Lebecq, L. Colin, A. Fangain, F. D. Stevens, J. Bareille, O. Hamant, Y. Belkhadir, T. Munnik, Y. Jaillais* and M.-C. Caillaud* (2021). "Inducible depletion of PI(4,5)P2 by the synthetic iDePP system in Arabidopsis." Nature Plants 7(5) : 587-597. Nature Plants
The paper above was featured in Nature Plants by news and views commentary by Bo Liu and Xiaojiang Guo “Disarming PI(4,5)P2 in the plasma membrane”

Doumane, M., C. Lionnet, V. Bayle, Y. Jaillais and M. C. Caillaud* (2017). "Automated Tracking of Root for Confocal Time-lapse Imaging of Cellular Processes." bio-protocol

Simon, M. L., M. P. Platre, M. M. Marques-Bueno, L. Armengot, T. Stanislas, V. Bayle, M. C. Caillaud* and Y. Jaillais* (2016). "A PtdIns(4)P-driven electrostatic field controls cell membrane identity and signalling in plants." Nature Plants

• First author (peer-reviewed)

Caillaud, MC, Wirthmueller L, Sklenar J, Findlay K, Piquerez SJ, Jones AM, Robatzek S, Jones JD and Faulkner C (2014). The plasmodesmal protein PDLP1 localises to haustoria-associated membranes during downy mildew infection and regulates callose deposition. PLoS Pathogen

Caillaud MC, Asai S, Rallapalli G, Piquerez SJ, Fabro G, Jones JD (2013). An Arabidopsis downy mildew Effector Attenuates Salicylic Acid-Triggered Immunity (SATI) via interactions with the host Mediator complex. PLoS Biology

Caillaud MC, Piquerez SJ, Fabro G, Steinbrenner J, Ishaque N, Beynon J, Jones JD (2012). Subcellular localisation of the Hpa RxLR effector repertoire identifies a tonoplast-associated protein HaRxL17 that confers enhanced plant susceptibility. Plant Journal

Caillaud MC, Paganelli L, Lecomte P, Deslandes L, Quentin M, Pecrix Y, Le Bris M, Marfaing N, Abad P, Favery B (2009). Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division. PLoS One

Caillaud MC, Lecomte P, Jammes F, Quentin M, Pagnotta S, Andrio E, de Almeida Engler J, Marfaing N, Gounon P, Abad P, Favery B (2008). MAP65-3 microtubule-associated protein is essential for nematode-induced giant cell ontogenesis in Arabidopsis. The Plant Cell

• Contributing author (peer-reviewed)
  Saile, S. C., F. M. Ackermann, S. Sunil, J. Keicher, A. Bayless, V. Bonardi, L. Wan, M. Doumane, E. Stöbbe, Y. Jaillais, M.-C. Caillaud, J. L. Dangl, M. T. Nishimura, C. Oecking and F. El Kasmi (2021). "Arabidopsis ADR1 helper NLR immune receptors localize and function at the plasma membrane in a phospholipid dependent manner." New Phytologist

Noack, L., V. Bayle, L. Armengot, F. Rozier, A. Mamode-Cassim, F. Stevens, M. C. Caillaud, T. Munnik, S. Mongrand and Y. Jaillais (2021). "A nanodomain anchored-scaffolding complex is required for PI4Kα function and localization in plants." The Plant Cell

Platre MP, Noack LC, Doumane M, Bayle V, Simon MLA, Maneta-Peyret L, Fouillen L, Stanislas T, Armengot L, Pejchar P, Caillaud MC, Potocky M, Copic A, Moreau P, Jaillais Y (2018) A Combinatorial Lipid Code Shapes the Electrostatic Landscape of Plant Endomembranes. Developmental Cell

Quentin, M., I. Baures, C. Hoefle, M. C. Caillaud, V. Allasia, F. Panabieres, P. Abad, R. Huckelhoven, H. Keller and B. Favery (2016). The Arabidopsis microtubule-associated protein MAP65-3 supports infection by filamentous biotrophic pathogens by down-regulating salicylic acid-dependent defenses. J Exp Bot

Wirthmueller, L., C. Roth, G. Fabro, M. C. Caillaud, G. Rallapalli, S. Asai, J. Sklenar, A. M. Jones, M. Wiermer, J. D. Jones and M. J. Banfield (2015). Probing formation of cargo/importin-alpha transport complexes in plant cells using a pathogen effector. Plant Journal

Asai, S., G. Rallapalli, S. J. Piquerez, M. C. Caillaud, O. J. Furzer, N. Ishaque, L. Wirthmueller, G. Fabro, K. Shirasu and J. D. Jones (2014). Expression profiling during arabidopsis/downy mildew interaction reveals a highly-expressed effector that attenuates responses to salicylic acid. PLoS Pathogen

Fabro G, Steinbrenner J, Coates M, Ishaque N, Baxter L, Studholme DJ, Korner E, Allen RL, Piquerez SJ, Rougon-Cardoso A, Greenshields D, Lei R, Badel JL, Caillaud MC, Sohn KH, Van den Ackerveken G, Parker JE, Beynon J, Jones JD (2011). Multiple candidate effectors from the oomycete pathogen Hyaloperonospora arabidopsidis suppress host plant immunity. PLoS Pathogen

Abad P, Gouzy J, Aury JM, Castagnone-Sereno P, Danchin EG, Deleury E, Perfus-Barbeoch L, Anthouard V, Artiguenave F, Blok VC, Caillaud MC, Coutinho plasma membrane, Dasilva C, De Luca F, Deau F, Esquibet M, Flutre T, Goldstone JV, et al., (2008). Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita. Nature Biotech

• Review (and not peer-reviewed papers)
  Goldy C., M. C. Caillaud* (in press) Linking the plant cytoskeleton to membranes via the anionic lipids. Current Opinion in Plant Biology doi 10.1016/j.pbi.2023.102365

Caillaud, M. C. (2022). Tools for studying the cytoskeleton during plant cell division. Trends in Plant Science

Doumane, M., M.-C. Caillaud* and Y. Jaillais* (2022) “Experimental Manipulation of Phosphoinositide lipids, from cells to organisms” Trends in Cell Biology

Caillaud, M. C., (2022) Methods to visualize the Actin Cytoskeleton During Plant Cell Division, Method in Molecular Biology

Caillaud, M.-C., (2022) Plant cell division : methods and protocols. Preface, Methods in Molecular Biology

Colin, L., R. Martin-Arevalillo, S. Bovio, A. Bauer, T. Vernoux, M. C. Caillaud, B. Landrein and Y. Jaillais (2021). "Imaging the living plant cell : from probes to quantification." The Plant Cell

Doumane, M. and M. C. Caillaud* (2020). "Assessing Extrinsic Membrane Protein Dependency to PI4P Using a Plasma Membrane to Endosome Relocalization Transient Assay in Nicotiana benthamiana." Methods Mol Biol

Caillaud, M.-C. (2019) Anionic Lipids : a Pipeline Connecting Key Players of Plant Cell Division. Frontiers in Plant Sciences

Caillaud, M.-C., (2016) Plant cell division : methods and protocols. Preface, Methods in Molecular Biology

Caillaud, M. C. and B. Favery (2016). "In Vivo Imaging of Microtubule Organization in Dividing Giant Cell." Methods Mol Biol

Caillaud MC, Wirthmueller L, Fabro G, Piquerez SJ, Asai S, Ishaque N, Jones JD (2013). Mechanisms of Nuclear Suppression of Host Immunity by Effectors from the Arabidopsis Downy Mildew Pathogen Hyaloperonospora arabidopsidis (Hpa). Cold Spring Harb Symp Quant Biol

Caillaud MC, Dubreuil G, Quentin M, Perfus-Barbeoch L, Lecomte P, de Almeida Engler J, Abad P, Rosso MN, Favery B (2008). Root-knot nematodes manipulate plant cell functions during a compatible interaction. J Plant Physiol

Caillaud MC, Abad P, Favery B (2008). Cytoskeleton reorganization, a key process in root-knot nematode-induced giant cell ontogenesis. Plant Signal Behav