François ROUDIER
francois.roudier
(33) 4 72 72 86 04
PU ENS
Publications
Annick DUBOIS
annick.dubois
(33) 4 72 72 14 76
CR1 INRA
Publications
Françoise MONEGER
francoise.moneger
(33) 4 72 72 89 85
DR2 CNRS
Publications
Aurélie VIALETTE
aurelie.vialette
(33) 4 72 72 14 79
AGPR ENS
Virginie BATTU
virginie.battu
(33) 4 72 72 86 07
TR UCBL
Alice HUGUES
alice.hugues
Doctorante
Bertrand HUGUENIN-BIZOT
bertrand.huguenin-bizot
IE CNRS
Daniel BOUYER
daniel.bouyer
(33) 4 72 72 86 11
CRN CNRS
Publications
Jérémy JUST
jeremy.just
(33)4 72 72 86 11
IR CNRS
Publications
Marie France GERENTES
marie-france.gerentes
(33) 4 72 72 14 77
AI ENS CDD
Nathalie MATHY-FRANCHET
nathalie.mathy-franchet
(33) 4 72 72 86 11
AI CNRS
Nicolas DALLE
nicolas.dalle
(33) 4 26 73 14 72
Doctorant
2023
Journal articles
- titre
- The Arabidopsis transcription factor NLP2 regulates early nitrate responses and integrates nitrate assimilation with energy and carbon skeleton supply
- auteur
- Mickaël Durand, Virginie Brehaut, Gilles Clement, Zsolt Kelemen, Julien Macé, Regina Feil, Garry Duville, Alexandra Launay-Avon, Christine Paysant-Le Roux, John Lunn, François Roudier, Anne Krapp
- article
- The Plant cell, 2023, ⟨10.1093/plcell/koad025⟩
- Accès au bibtex
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2021
Journal articles
- titre
- Deciphering Plant Chromatin Regulation via CRISPR/dCas9-Based Epigenome Engineering
- auteur
- Annick Dubois, François Roudier
- article
- Epigenomes, 2021, 5 (3), pp.17. ⟨10.3390/epigenomes5030017⟩
- Accès au texte intégral et bibtex
-
- titre
- A network of transcriptional repressors modulates auxin responses.
- auteur
- Jekaterina Truskina, Jingyi Han, Elina Chrysanthou, Carlos Galvan-Ampudia, Stéphanie Lainé, Geraldine Brunoud, Julien Macé, Simon Bellows, Jonathan Legrand, Anne-Maarit Bågman, Margot Smit, Ondrej Smetana, Arnaud Stigniani, Silvana Porco, Malcom J. Bennett, Ari Pekka Mähönen, Francois Parcy, Etienne Farcot, François Roudier, Siobhan M Brady, Anthony Bishopp, Teva Vernoux
- article
- Nature, 2021, 589 (7840), pp.116-119. ⟨10.1038/s41586-020-2940-2⟩
- Accès au texte intégral et bibtex
-
2020
Journal articles
- titre
- Mitotic Inheritance of PRC2-Mediated Silencing: Mechanistic Insights and Developmental Perspectives
- auteur
- Alice Hugues, Chean Sern Jacobs, François Roudier
- article
- Frontiers in Plant Science, 2020, 11, ⟨10.3389/fpls.2020.00262⟩
- Accès au texte intégral et bibtex
-
- titre
- ChIP-seq and RNA-seq for complex and low-abundance tree buds reveal chromatin and expression co-dynamics during sweet cherry bud dormancy
- auteur
- Noémie Vimont, Fu Xiang Quah, David Guillaume Schöpfer, François Roudier, Elisabeth Dirlewanger, Philip A. Wigge, Bénédicte Wenden, Sandra Cortijo
- article
- Tree Genetics and Genomes, 2020, 16 (1), pp.9. ⟨10.1007/s11295-019-1395-9⟩
- Accès au bibtex
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2019
Journal articles
- titre
- Histone acetylation orchestrates wound-induced transcriptional activation and cellular reprogramming in Arabidopsis
- auteur
- Bart Rymen, Ayako Kawamura, Alice Lambolez, Soichi Inagaki, Arika Takebayashi, Akira Iwase, Yuki Sakamoto, Kaori Sako, David Favero, Momoko Ikeuchi, Takamasa Suzuki, Motoaki Seki, Tetsuji Kakutani, François Roudier, Keiko Sugimoto
- article
- Communications Biology, 2019, 2, ⟨10.1038/s42003-019-0646-5⟩
- Accès au texte intégral et bibtex
-
Preprints, Working Papers, ...
- titre
- ChIP-seq and RNA-seq for complex and low-abundance tree buds reveal chromatin and expression co-dynamics during sweet cherry bud dormancy
- auteur
- Noémie Vimont, Fu Xiang Quah, David Guillaume-Schöpfer, François Roudier, Elisabeth Dirlewanger, Philip A. Wigge, Bénédicte Wenden, Sandra Cortijo
- article
- 2019
- Accès au texte intégral et bibtex
-
2018
Book sections
- titre
- Cell Type-Specific Profiling of Chromatin Modifications and Associated Proteins
- auteur
- Ana Karina Morao, Erwann E. Caillieux, Vincent Colot, François Roudier
- article
- Plant Chromatin Dynamics, pp.111-130, 2018, ⟨10.1007/978-1-4939-7318-7_8⟩
- Accès au bibtex
-
- titre
- Chromatin Immunoprecipitation Sequencing (ChIP-Seq) for Transcription Factors and Chromatin Factors in Arabidopsis thaliana Roots: From Material Collection to Data Analysis
- auteur
- Sandra S. Cortijo, Varodom Charoensawan, François Roudier, Philip A. Wigge
- article
- Root Development, pp.231-248, 2018, ⟨10.1007/978-1-4939-7747-5_18⟩
- Accès au bibtex
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2017
Journal articles
- titre
- Epigenetic memory and cell fate reprogramming in plants
- auteur
- Kenneth D. Birnbaum, François Roudier
- article
- Regeneration, 2017, 4 (1), pp.15-20. ⟨10.1002/reg2.73⟩
- Accès au bibtex
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2016
Journal articles
- titre
- Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation
- auteur
- Miguel De Lucas, Li Pu, Gina Turco, Allison Gaudinier, Ana Karina Morao, Hirofumi Harashima, Dahae Kim, Mily Ron, Keiko Sugimoto, François Roudier, Siobhan M. Brady
- article
- The Plant cell, 2016, 28 (10), pp.2616-2631. ⟨10.1105/tpc.15.00744⟩
- Accès au bibtex
-
- titre
- Emerging concepts in chromatin-level regulation of plant cell differentiation: timing, counting, sensing and maintaining
- auteur
- Ana Karina Morao, Daniel Bouyer, François Roudier
- article
- Current Opinion in Plant Biology, 2016, 34, pp.27-34. ⟨10.1016/j.pbi.2016.07.010⟩
- Accès au bibtex
-
Our research aims at understanding the extent to which chromatin-based mechanisms and epigenetic processes regulate cell fate acquisition, maintenance and reprogramming during plant development.
How cell acquire and maintain their identity during development is indeed a central question in biology. Whereas cell identity is largely dictated by the transcriptional profiles resulting from the activity of specific transcription factors (TFs), the robustness of this state depends on the chromatin context in which these TFs act. Thus, the progression of a cell through successive differentiation stages, from stem cells to end-differentiated cells, is guided by changes in transcriptional programs that are regulated by the bidirectional interplay between TFs and chromatin organization.
In order to understand how epigenome dynamics enable cells to respond selectively to developmental and environmental cues, we develop complementary approaches aimed at characterizing the impact of chromatin-based mechanisms and epigenetic processes on the regulation of cell differentiation within Arabidopsis apical meristems. A particular emphasis is put on the transcriptional repressive pathways associated with proteins of the Polycomb group.
Three research axes, included in a systemic approach that combines genetic, molecular, imaging and genomic approaches at cellular resolution are implemented in order to:
– characterize epigenome dynamics during cell differentiation and reveal the specific role of chromatin regulators in the activity of stem cell niches, cell fate acquisition and identity maintenance.
– determine the impact of chromatin state dynamics on the target repertoire of select transcription factors (and vice-versa) within specific cell populations.
– evaluate how epigenomic variation contributes to shaping developmental programs during evolution.
| Team members | . |
| François Roudier | Professor ENS (Group leader) |
| Daniel Bouyer | Senior Researcher CNRS (co-group leader) |
| Françoise Monéger | Research Director CNRS |
| Annick Dubois | Senior Researcher INRA |
| Nathalie Franchet-Mathy | Assistant Engineer CNRS |
| Virginie Battu | Research technician UCBL |
| Jérémy Just (40%) | Research Engineer bioinformatics CNRS |
| Aurélie Vialette | Lecturer ENS - postdoc |
| Marie France Gérentes | Engineer ENS |
| Bertrand Huguenin-Bizot | Engineer bioinformatics CNRS |
| Nicolas Dalle | PhD Student (ED bmic) |
| Alice Hugues | PhD Student (ED bmic) |
| Alumni | |
|---|---|
| Allan Bernard | Biosciences Master2 student |
| Mohammad Muhieddine | Biosciences Master2 student |
| Tristan Conot | Pre-master student ENS |
| Julia Buttin | Engineer in bioinformatics |
| Goeffrey Schivre | Master1 student U. Montpellier |
| Alice Hugues | Master2 student ENS |
| Chean Sern Jacobs | PhD Student (ED bmic) |
| Marie Biharé | Master1 student U. Lille |
| Laure Cuby | Pre-master student ESTBB Lyon |
| Lucas Auroux | Master2 student U. Strasbourg |
| Emma Désert | Master1 student UCBL1 |
| Colline Richard | Pre-master student ENS |
| Julien Macé | IE Bioinformatics ENS |