Research teams
- Seed Development
- Epigenetics, Chromatin and Development
- Evolution and Development of the Flower
- Mechanotransduction in Development
- Floral Morphogenesis
- Cell Signalling and Endomembranes
- Hormonal Signalling and Development
- MOrphogenesis Simulation and Analysis In siliCo (MOSAIC)
- [Bioinformatics Hub]
François ROUDIER
francois.roudier
(33) 4 72 72 86 04
PU ENS
Publications
Annick DUBOIS
annick.dubois
(33) 4 72 72 14 76
CR1 INRA
Publications
Aurélie VIALETTE
aurelie.vialette
(33) 4 72 72 14 79
PRAG ENS
Virginie BATTU
virginie.battu
(33) 4 72 72 86 07
TR UCBL
Bertrand HUGUENIN-BIZOT
bertrand.huguenin-bizot
IE CNRS
Daniel BOUYER
daniel.bouyer
(33) 4 72 72 86 11
CRN CNRS
Publications
Laëtitia De Faria
Laëtitia De Faria
Doctorante
Nathalie MATHY-FRANCHET
nathalie.mathy-franchet
(33) 4 72 72 86 11
AI CNRS
2025
Journal articles
- titre
- Polycomb Repressive Complex 2 facilitates the transition from heterotrophy to photoautotrophy during seedling emergence
- auteur
- Naseem Samo, María Guadalupe Trejo-Arellano, Lenka Gahurová, Alexander Erban, Alina Ebert, Quentin Rivière, Jiří Kubásek, Fatemeh Aflaki, Helena Hönig Mondeková, Armin Schlereth, Annick Dubois, Mingxi Zhou, Ondřej Novák, Jiří Šantrůček, Daniel Bouyer, Francois Roudier, Joachim Kopka, Iva Mozgová
- article
- The Plant cell, 2025, ⟨10.1093/plcell/koaf148⟩
- Accès au bibtex
-
- titre
- Synthetic deconvolution of an auxin-dependent transcriptional code
- auteur
- Raquel Martin-Arevalillo, Bruno Guillotin, Jonas Schön, Alice Hugues, Marie-France Gerentes, Jeremy Lucas, Emmanuel Thevenon, Graeme Vissers, Mohammed Mohammed Ateequr, Carlos Galvan-Ampudia, Guillaume Cerutti, Jonathan Legrand, Coralie Cancé, Annick Dubois, François Parcy, Kenneth D. Birnbaum, Matias D Zurbriggen, Renaud Dumas, François Roudier, Teva Vernoux
- article
- Cell, 2025, ⟨10.1016/j.cell.2025.03.028⟩
- Accès au texte intégral et bibtex
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2024
Journal articles
- titre
- MIR164B ensures robust Arabidopsis leaf development by compensating for compromised POLYCOMB REPRESSIVE COMPLEX2 function
- auteur
- Aude Maugarny, Aurélie Vialette, Bernard Adroher, Anne-Sophie Sarthou, Nathalie Mathy-Franchet, Marianne Azzopardi, Antoine Nicolas, François Roudier, Patrick Laufs
- article
- The Plant cell, 2024, ⟨10.1093/plcell/koae260⟩
- Accès au texte intégral et bibtex
-
Preprints, Working Papers, ...
- titre
- PRC2 facilitates the transition from heterotrophy to photoautotrophy during seedling emergence
- auteur
- Naseem Samo, María Guadalupe Trejo-Arellano, Lenka Gahurová, Alexander Erban, Alina Ebert, Quentin Rivière, Jiří Kubásek, Fatemeh Aflaki, Helena Hönig Mondeková, Armin Schlereth, Annick Dubois, Mingxi Zhou, Ondřej Novák, Jiří Šantrůček, Daniel Bouyer, Franҫois Roudier, Joachim Kopka, Iva Mozgová
- article
- 2024
- Accès au texte intégral et bibtex
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2023
Journal articles
- titre
- The Arabidopsis transcription factor NLP2 regulates early nitrate responses and integrates nitrate assimilation with energy and carbon skeleton supply
- auteur
- Mickaël Durand, Virginie Brehaut, Gilles Clement, Zsolt Kelemen, Julien Macé, Regina Feil, Garry Duville, Alexandra Launay-Avon, Christine Paysant-Le Roux, John Lunn, François Roudier, Anne Krapp
- article
- The Plant cell, 2023, 35 (5), pp.1429-1454. ⟨10.1093/plcell/koad025⟩
- Accès au bibtex
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2021
Journal articles
- titre
- Deciphering Plant Chromatin Regulation via CRISPR/dCas9-Based Epigenome Engineering
- auteur
- Annick Dubois, François Roudier
- article
- Epigenomes, 2021, 5 (3), pp.17. ⟨10.3390/epigenomes5030017⟩
- Accès au texte intégral et bibtex
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- titre
- Editorial overview: Multifaceted dynamics and countless shades of green chromatin
- auteur
- Mary Gehring, François Roudier
- article
- Current Opinion in Plant Biology, 2021, 61, pp.102079. ⟨10.1016/j.pbi.2021.102079⟩
- Accès au bibtex
-
- titre
- A network of transcriptional repressors modulates auxin responses.
- auteur
- Jekaterina Truskina, Jingyi Han, Elina Chrysanthou, Carlos Galvan-Ampudia, Stéphanie Lainé, Geraldine Brunoud, Julien Macé, Simon Bellows, Jonathan Legrand, Anne-Maarit Bågman, Margot Smit, Ondrej Smetana, Arnaud Stigniani, Silvana Porco, Malcom J. Bennett, Ari Pekka Mähönen, Francois Parcy, Etienne Farcot, François Roudier, Siobhan M Brady, Anthony Bishopp, Teva Vernoux
- article
- Nature, 2021, 589 (7840), pp.116-119. ⟨10.1038/s41586-020-2940-2⟩
- Accès au texte intégral et bibtex
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2020
Journal articles
- titre
- Mitotic Inheritance of PRC2-Mediated Silencing: Mechanistic Insights and Developmental Perspectives
- auteur
- Alice Hugues, Chean Sern Jacobs, François Roudier
- article
- Frontiers in Plant Science, 2020, 11, ⟨10.3389/fpls.2020.00262⟩
- Accès au texte intégral et bibtex
-
- titre
- ChIP-seq and RNA-seq for complex and low-abundance tree buds reveal chromatin and expression co-dynamics during sweet cherry bud dormancy
- auteur
- Noémie Vimont, Fu Xiang Quah, David Guillaume Schöpfer, François Roudier, Elisabeth Dirlewanger, Philip A. Wigge, Bénédicte Wenden, Sandra Cortijo
- article
- Tree Genetics and Genomes, 2020, 16 (1), pp.9. ⟨10.1007/s11295-019-1395-9⟩
- Accès au texte intégral et bibtex
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2019
Journal articles
- titre
- Histone acetylation orchestrates wound-induced transcriptional activation and cellular reprogramming in Arabidopsis
- auteur
- Bart Rymen, Ayako Kawamura, Alice Lambolez, Soichi Inagaki, Arika Takebayashi, Akira Iwase, Yuki Sakamoto, Kaori Sako, David Favero, Momoko Ikeuchi, Takamasa Suzuki, Motoaki Seki, Tetsuji Kakutani, François Roudier, Keiko Sugimoto
- article
- Communications Biology, 2019, 2, ⟨10.1038/s42003-019-0646-5⟩
- Accès au texte intégral et bibtex
-
- titre
- The m 6 A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants
- auteur
- Dominique Pontier, Claire Picart, Moaine El Baidouri, François Roudier, Tao Xu, Sylvie Lahmy, Christel Llauro, Jacinthe Azevedo, Michèle Laudié, Aurore Attina, Christophe Hirtz, Marie-Christine Carpentier, Lisha Shen, Thierry Lagrange
- article
- Life Science Alliance, 2019, 2 (3), pp.e201900393. ⟨10.26508/lsa.201900393⟩
- Accès au texte intégral et bibtex
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Preprints, Working Papers, ...
- titre
- ChIP-seq and RNA-seq for complex and low-abundance tree buds reveal chromatin and expression co-dynamics during sweet cherry bud dormancy
- auteur
- Noémie Vimont, Fu Xiang Quah, David Guillaume-Schöpfer, François Roudier, Elisabeth Dirlewanger, Philip A. Wigge, Bénédicte Wenden, Sandra Cortijo
- article
- 2019
- Accès au texte intégral et bibtex
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2018
Book sections
- titre
- Cell Type-Specific Profiling of Chromatin Modifications and Associated Proteins
- auteur
- Ana Karina Morao, Erwann E. Caillieux, Vincent Colot, François Roudier
- article
- Plant Chromatin Dynamics, pp.111-130, 2018, ⟨10.1007/978-1-4939-7318-7_8⟩
- Accès au bibtex
-
- titre
- Chromatin Immunoprecipitation Sequencing (ChIP-Seq) for Transcription Factors and Chromatin Factors in Arabidopsis thaliana Roots: From Material Collection to Data Analysis
- auteur
- Sandra S. Cortijo, Varodom Charoensawan, François Roudier, Philip A. Wigge
- article
- Root Development, pp.231-248, 2018, ⟨10.1007/978-1-4939-7747-5_18⟩
- Accès au bibtex
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2017
Journal articles
- titre
- Epigenetic memory and cell fate reprogramming in plants
- auteur
- Kenneth D. Birnbaum, François Roudier
- article
- Regeneration, 2017, 4 (1), pp.15-20. ⟨10.1002/reg2.73⟩
- Accès au texte intégral et bibtex
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2016
Journal articles
- titre
- A versatile Multisite Gateway-compatible promoter and transgenic line collection for cell type-specific functional genomics in Arabidopsis
- auteur
- Maria Mar Marquès-Bueno, Ana K. Morao, Anne Cayrel, Matthieu P. Platre, Marie Barberon, Erwann Caillieux, Vincent Colot, Yvon Jaillais, François Roudier, Grégory Vert
- article
- The Plant Journal, 2016, 85 (2), pp.320--333. ⟨10.1111/tpj.13099⟩
- Accès au texte intégral et bibtex
-
- titre
- Emerging concepts in chromatin-level regulation of plant cell differentiation: timing, counting, sensing and maintaining
- auteur
- Ana Karina Morao, Daniel Bouyer, François Roudier
- article
- Current Opinion in Plant Biology, 2016, 34, pp.27-34. ⟨10.1016/j.pbi.2016.07.010⟩
- Accès au bibtex
-
Our research aims at understanding the extent to which chromatin-based mechanisms and epigenetic processes regulate cell fate acquisition, maintenance and reprogramming during plant development.
How cell acquire and maintain their identity during development is indeed a central question in biology. Whereas cell identity is largely dictated by the transcriptional profiles resulting from the activity of specific transcription factors (TFs), the robustness of this state depends on the chromatin context in which these TFs act. Thus, the progression of a cell through successive differentiation stages, from stem cells to end-differentiated cells, is guided by changes in transcriptional programs that are regulated by the bidirectional interplay between TFs and chromatin organization.
In order to understand how epigenome dynamics enable cells to respond selectively to developmental and environmental cues, we develop complementary approaches aimed at characterizing the impact of chromatin-based mechanisms and epigenetic processes on the regulation of cell differentiation within Arabidopsis apical meristems. A particular emphasis is put on the transcriptional repressive pathways associated with proteins of the Polycomb group.
Three research axes, included in a systemic approach that combines genetic, molecular, imaging and genomic approaches at cellular resolution are implemented in order to:
– characterize epigenome dynamics during cell differentiation and reveal the specific role of chromatin regulators in the activity of stem cell niches, cell fate acquisition and identity maintenance.
– determine the impact of chromatin state dynamics on the target repertoire of select transcription factors (and vice-versa) within specific cell populations.
– evaluate how epigenomic variation contributes to shaping developmental programs during evolution.
| Team members | . |
| François Roudier | Professor ENS (Group leader) |
| Daniel Bouyer | Senior Researcher CNRS (co-group leader) |
| Annick Dubois | Senior Researcher INRA |
| Nathalie Franchet-Mathy | Assistant Engineer CNRS |
| Virginie Battu | Research technician UCBL |
| Bertrand Huguenin-Bizot | Engineer bioinformatics CNRS |
| Laëtitia De Faria | PhD Student (ED bmic) |
Alumni
Allan Bernard (ENS Master2 student)
Mohammad Muhieddine (ENS Master2 student)
Tristan Conot (Pre-master student ENS)
Julia Buttin (Engineer in bioinformatics)
Goeffrey Schivre (Master1 student U. Montpellier)
Alice Hugues (Master2 student ENS)
Chean Sern Jacobs (PhD Student, ED bmic)
Marie Biharé (Master1 student U. Lille)
Laure Cuby (Pre-master student ESTBB Lyon)
Lucas Auroux (Master2 student U. Strasbourg)
Emma Désert (Master1 student UCBL1)
Colline Richard (Pre-master student ENS)
Julien Macé (IE Bioinformatics ENS)
Aurélie Vialette (Lecturer ENS - postdoc)
Marie France Gérentes (Engineer ENS)
Nicolas Dalle (PhD Student & ATER UCBL)
Marjorie Sublet (ESTBB bachelor student)
Mattéo Veyre (Sup Biotech student)
Alice Hugues (PhD Student, ED bmic)
Aleksandra Lefevre (M1 student ENS)
Jérémy Just (40%, Research Engineer bioinformatics CNRS)
Françoise Monéger (Research Director CNRS, Retired)