RDP Seminar Emmanuelle Bayer

Plasmodesmata : cellular machines for inter and intracellular communication ?

RDP seminar by Emmanuelle Bayer from the Laboratoire de Biogenèse membranaire (Bordeaux, France)

Intercellular communication is critical for multicellularity. It coordinates the activities within individual cells to support the function of an organism as a whole. Plants have developed remarkable cellular machines -the Plasmodesmata (PD) pores- which interconnect every single cell within the plant body, establishing direct membrane and cytoplasmic continuity, a situation unique to plants. PD are indispensable for plant life. They control the flux of molecules between cells and are decisive for development, environmental adaptation and defence signalling. However, how PD integrate signalling to coordinate responses at a multicellular level remains unclear. A striking feature of PD organisation, setting them apart from animal cell junctions, is a strand of endoplasmic reticulum (ER) running through the pore, tethered extremely tight ( 10nm) to the plasma membrane (PM) by unidentified “spokes”. To date, the function of ER-PM contacts at PD remains a complete enigma. We don’t know how and why the two organelles come together at PD cellular junctions. Using a combination of proteomic approaches, biophysical/modelling methods and ultra-high resolution 3D imaging into molecular cell biology of plant cell-to-cell communication, our lab is trying to address the mechanism and function of ER-PM contacts at PD.

Date : Monday, March 19th
Time : 11am
Location : Salle des Thèses

Selected publications
 W. J. Nicolas, M. S. Grison, S. Trépout, A. Gaston, M. Fouché, F. P. Cordelières, K. Oparka, J. Tilsner, L. Brocard, and E. M. Bayer (2017). Post-cytokinesis plasmodesmata with no cytoplasmic sleeve are open for macromolecule trafficking Accepted in Nature Plants
 Tilsner J, Nicolas W. Rosado A and Bayer E.M. (2016) Staying tight : plasmodesmal membrane contact sites and the control of cell-to-cell connectivity in plants. Annual Review of Plant Biology 67:23.1-23.28.
 Grison MS, Brocard L, Fouillen L, Nicolas W, Wewer V , Dörmann P, Nacir H, Benitez-Alfonso Y, Claverol S, Germain V, Boutté Y, Mongrand S and Bayer EM (2015). Specific membrane lipid composition is important for plasmodesmata function. The plant Cell 27(4):1228-50.
 Grison MS, Calvino-Fernandez L, Mongrand S, Bayer EM (2015). Isolation of Plasmodesmata from Arabidopsis Suspension Cell Culture for Lipidomic and Proteomic Analyses. Methods in Molecular Biology. (1217):83-93.
 Bayer EM, Mongrand S, Tilsner J. (2014). Specialized membrane domains of plasmodesmata, plant intercellular nanopores. Frontiers in Plant Science doi : 10.3389/fpls.2014.00507. Editor review article.

RDP host : Yvon Jaillais

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