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Christophe GODIN
christophe.godin
DR INRIA
Publications
Guillaume CERUTTI
guillaume.cerutti
IR INRAe
Publications
Annamaria KISS
annamaria.kiss
(33) 4 72 72 89 37
IR INRAE
Publications
Jonathan LEGRAND
jonathan.legrand
(33)4 72 72 86 04
IR CNRS
Publications
Manuel PETIT
manuel.petit
(33) 4 72 72 89 37
IR INRIA
Publications
Adrien MARION
adrien.marion
Ph.D student
Aurèle BOUSSARD
aurele.boussard
Postdoc
Florian ALONSO
(he/him)
florian.alonso
Engineer (ERC-funded)
Gauthier WEISSBART
(he/him)
gauthier.weissbart
Postdoc (ERC-funded)
Gonzalo REVILLA
gonzalo.revilla
ADT Engineer INRIA
Henri PECHOUX
henri.pechoux
Ph.D student
John THAMPI
john.thampi
Ph.D student (ERC-funded)
Justina STARK
justina.stark
Postdoc
Lucie POUPARDIN
lucie.poupardin
Ph.D student Inria-INRAe
2026
Journal articles
Preprints, Working Papers, ...
2025
Journal articles
Preprints, Working Papers, ...
2024
Journal articles
Preprints, Working Papers, ...
2023
Journal articles
Preprints, Working Papers, ...
2022
Journal articles
Book sections
Preprints, Working Papers, ...
2021
Journal articles
Preprints, Working Papers, ...
2020
Journal articles
2019
Journal articles
Preprints, Working Papers, ...
2018
Journal articles
Book sections
Books
Preprints, Working Papers, ...
Our general aim is to identify key principles of organism development by constructing mathematical and computational models based on explicit representations of forms. For this, we develop a dual modeling approach where conceptual models are used to identify self-organizing principles and realistic models based on 3D imaging to test non-trivial genetic and physical hypotheses in silico. The team tightly collaborates with several teams of biologists with whom it shares biological questions and develops new methods.
While our approach mainly focuses on plant development at different scales, the MOSAIC team also considers the morphogenesis of model animal systems, such as ascidians, to cross-fertilize the approaches and to open the possibility to identify abstractions and principles that are relevant to the morphogenesis of living forms in general. Our work concentrates on how physical and chemical processes interact within the medium defined by the form and feedback on its development. We seek in particular to integrate both mechanistic and stochastic components in our models to account for biological variability in shape development.
On the technical level, the team develops and explores the use of computational and mathematical concepts within a large variety of domains : form algebra, ODE/PDE, dynamical systems, fractals, stochastic processes, continuum mechanics, FEM, information theory, graph theory, computational geometry, and unconventional programming languages.
Our research program is organized along three main research axes.
The modeling of organism development requires a formalization of the concept of form, i.e. a mathematical definition of what is a form and how it can change over time. This goes together with the development of efficient algorithms to construct corresponding computational representations from observations, manipulate them, and associate local molecular and physical information with them.
Sub-axes :
Models of key processes participating in different aspects of morphogenesis (signaling, transport, molecular regulation, cell division, etc.) are developed and tested in silico on 3D data structures reconstructed from digitized forms. The way these component-based models scale up at more abstract levels, where forms can be considered as continuums, is investigated, and the simulation results are compared with actual form development.
Sub-axes :
Building on the insights gained from axes 1 and 2 on the mechanisms driving form development, we aim to explore the mechanistic origin of form plasticity and robustness. In this context, we study the ability of specific developmental mechanisms to buffer, or even to exploit biological noise during morphogenesis. For plants, we develop models capturing morphogenetic reactions to specific environmental changes (such as water stress), and their ability to modulate or even to reallocate growth opportunistically.
Sub-axes :
The team develops software and a computational platform for analysis and simulation of morphogenesis in 3D. More information.
– Teva Vernoux (RDP)
– Benoit Landrein (RDP)
– Marie-Cécile Caillaud (RDP)
– Emmanuel Faure (LIRMM - Univ. Montpellier)
– Patrick Lemaire (CRBM - Univ. Montpellier)
– Grégoire Malandain (Morpheme - Inria Sophia Antipolis)
– Arezki Boudaoud (LadHyx - Ecole Polytechnique)
– Ibrahim Cheddadi (Université Grenoble Alpes)
– Frederic Boudon (CIRAD)
– Dražen Zanchi (Laboratoire MSC Paris)
