Benoit Landrein (PhD)
CNRS Researcher (CR-CN), Seed Mechanics Group
Team Seed Development Laboratory of Plant Reproduction and Development (RDP), ENS de Lyon, France
Google scholar ORCID

Employment History
• Since 2018 CNRS Researcher
Laboratory of Plant Reproduction and Development, ENS de Lyon (France)
“Mechanical control of seed development”

• 2014 – 2018 Research Associate (Post-Doc)
The Sainsbury Laboratory, University of Cambridge (UK)
Supervisors : Pr. Henrik Jönsson, Dr. James Locke and Pr. Elliot Meyerowitz
“Molecular mechanisms of developmental plasticity in Arabidopsis shoot apical meristem”

• 2014 – 2018 PhD student
Laboratory of Plant Reproduction and Development, ENS de Lyon (France)
Supervisor : Dr. Olivier Hamant
“Linking patterning to growth during morphogenesis in Arabidopsis shoot apical meristem”

Academic Qualifications
2023 Habilitation to Direct Research (HDR), ENS de Lyon (France)
2014 Doctor of Philosophy (Biological Sciences), ENS de Lyon (France)
2010 Master in Biological Sciences, ENS de Lyon (France)
2008 Bachelor in Molecular Biology, ENS de Lyon (France)

Fellowships and Awards
2017 Young researcher award from the city of Lyon (Biosciences and Society)
2014 PhD award from the French society of Developmental Biology
2010 – 2014 PhD fellowship form the French ministry of higher education
2008 – 2010 Student fellowship from the French ministry of higher education

Research Grants
2023 – 2026 Young researcher grant from the French Agency of Research (ANR JC-JC, coordinator)
2020 – 2022 Research grant from the BAP department of INRAE (coordinator)
2020 – 2023 Research grant for a Joined PhD program between CNRS and University of
Melbourne with John Golz and Gwyneth Ingram (partner)
2019 – 2021 Research grant from the research fund of the ENS de Lyon (coordinator)

Teaching
Since 2021 Participation to Master course teachings at the University of Montpellier (4h/year)
Since 2019 Participation to Master course teachings at ENS de Lyon (around 4h/year)
2016 – 2017 Participation in the Gatsby Summer school on Plant Biology (UK, 2 x 1 week)
2010 – 2014 Teaching at the ENS de Lyon for Bachelor and Master students (200h)

Supervision
Since 2024 Supervisor of the Post-Doctorate of Jeanne Braat (CNRS)
Since 2021 Co-supervisor of the PhD of Runjue Yao, in collaboration with Gwyneth Ingram (RDP, France) and John Golz (University of Melbourne, Australia)
2020 - 2024 Supervisor of the PhD of Camille Bied (ENS de Lyon)
2020 - 2023 Co-supervisor of the PhD of Amélie Bauer, in collaboration with Gwyneth Ingram (RDP, France) and John Golz (University of Melbourne, Australia)
2018-2022 Co-supervisor of the PhD of Filipa Lopes (ITQB Nova, Portugal), in collaboration with Henrik Jönsson (SLCU, UK) and Elena Baena-Gonzalez (IGC, Portugal)
Since 2011 Primary supervisor of 7 master students

Administrative duties
Since 2024 Responsible of the Arabidopsis culture platform of the RDP
Since 2023 Board member of the French Seed Biology Network
Since 2021 Training correspondent of the RDP laboratory for the CNRS
Since 2020 Gender equality representative of the RDP laboratory for the CNRS
2022 - 2024 Scientific referent for the imaging platform (PLATIM) of the SFR128 Biosciences

Other activities

Member of 5 PhD defense committees :
Yosapol Harnvanichvech (2023, WUR (Netherlands), supervisors : D. Weijers and J. Sprakel, reviewer)
Rita Bastos Lima (2023, MPIMP (Germany), supervisor : D. Figueiredo, reviewer)
Yunji Huang (2023, IPSIM (France), supervisor : Y. Boursiac and Christophe Maurel, reviewer)
Camille Salaün (2023, IJPB (France), supervisor : B. Dubreucq, examiner)
Antoine Nicolas (2022, IJPB (France), supervisor : P. Laufs, examiner)

Member of 4 PhD monitoring committees :
Landry Duguet (supervisors : Christophe Godin and Teva Vernoux)
Sana Dieudonné (supervisor : Fabrice Besnard)
Alice Malivert (supervisor : Olivier Hamant)
Corentin Mollier (supervisor : Arezki Boudaoud)

Reviewer for scientific journals :
Current Biology, Nature Communications, The Plant Cell, EMBO Journal, iScience, The Plant Journal, New Phytologist, Biophysical Journal, Developmental Cell, Molecular Plant, Journal of Experimental Botany, Plant Reproduction, Frontiers in Plant Sciences, Communications Biology

Reviewer of grant proposals :
DFG (Germany), GACR (Czech republic), BBSRC (United Kingdom), NCN (Poland), SNSF (Switzerland) ; ETH Zurich (Switzerland)

Member of selection committees :
BMIC Doctoral school (2024, ENS de Lyon/University Lyon 1)
RePlant Doctoral Training Program (2023, CRAG (Spain) and MPIPZ (Germany))
SEVE Doctoral school (2022, University Paris-Saclay)

Organization of scientific event :
Co-organizer of the European Plant Cytoskeletal Club (EPCC) meeting (2025, Lyon, France)
Chair of the session on Biomechanics of the Plant Biology Europe meeting (2023, Marseille, France)
Member of the organizing committee of the Xth Plant Biomechanics Conference (2022, Lyon, France)
Member of the organizing committee of the colloquium of the French Seed Biology Network (2021, Lyon, France)

Collaborators :
Olivier Ali (RDP laboratory, France)
Gwyneth Ingram (RDP laboratory, France)
John Golz (University of Melbourne, Australia)
Elena Baena-Gonzalez (IGC, Portugal, now at the University of Oxford, UK)
Aline Voxeur (IJPB laboratory, INRAE Versailles, France)
Duarte Figueiredo (MPIMP, Potsdam, Germany)
Joris Sprakel (WUR, Wageningen, The Netherlands)
Thorsten Hamann (NTNU, Trondheim, Norway)
Helene Robert Boivison (CEITEC, Brno, Czech Republic)

Publications

Main research publications :
o Bauer A., Bied C., Delattre A., Ingram G., Golz J.G., Landrein B (2024) Spatiotemporally distinct responses to mechanical forces shape the developing seed of Arabidopsis EmboJ. https://doi.org/10.1038/s44318-024-00138-w

o Lopes L, Formosa-Jordan P, Malivert A, Margalha L, Confraria A, Feil R, Lunn J.E, Jönsson H*, Landrein B* and Baena-González E* (2024) Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis. PNAS. https://doi.org/10.1073/pnas.2408699121

o Creff A., Ali O*, Bied C., Bayle V, Ingram GC*, Landrein B*. (2023) Evidence that endosperm turgor pressure both promotes and restricts seed growth and size. Nature Communications. https://doi.org/10.1038/s41467-022-35542-5

o Landrein B, Formosa-Jordan P, Malivert A, Schuster C, Melnyk C, Yang W, Turnbull C, Meyerowitz EM*, Locke JCW* and Jönsson H* (2018) Nitrate modulates stem cell dynamics in Arabidopsis shoot meristems by regulating WUSCHEL expression through cytokinins. PNAS. https://doi.org/10.1073/pnas.1718670115

o Gruel J, Landrein B, Tarr P, Schuster C, Refahi Y, Sampathkumar A, Hamant O, Meyerowitz EM, Jönsson H (2016) An epidermis-driven mechanism positions and scales stem cell niches in plants. Science Advances. https://doi.org/10.1126/sciadv.1500989

o Landrein B, Kiss A, Sassi M, Chauvet A, Das P, Cortizo M, Laufs P, Takeda S, Aida M, Traas J, Vernoux T, Boudaoud A, Hamant O (2015) Mechanical stress contributes to the expression of the STM homeobox gene in Arabidopsis shoot meristems. eLife. https://doi.org/10.7554/elife.07811

o Landrein B, Refahi Y, Besnard F, Hervieux N, Mirabet V, Boudaoud A, Vernoux T, Hamant O (2015) Meristem size contributes to the robustness of phyllotaxis in Arabidopsis. J Exp Bot. https://doi.org/10.1093/jxb/eru482

o Landrein B, Lathe R, Bringmann M, Vouillot C, Ivakov A, Boudaoud A, Persson S, Hamant O (2013) Impaired cellulose synthase guidance leads to stem torsion and twists phyllotactic patterns in Arabidopsis. Current Biology. https://doi.org/10.1016/j.cub.2013.04.013

Other research publications :
o Lima RB, Pankaj R, Ehlert S, Finger P, Fröhlich A, Bayle V, Landrein B, Sampathkumar A, Figueiredo DD (2024) Seed coat-derived brassinosteroid signaling regulates endosperm development. Nature Communications. https://doi.org/10.1038/s41467-024-53671-x

o Yang W, Schuster C, Prunet N, Dong Q, Landrein B, Whightman R, Meyerowitz EMM (2019) Visualization of Protein Coding, Long Noncoding, and Nuclear RNAs by Fluorescence in Situ Hybridization in Sections of Shoot Apical Meristems and Developing Flowers. Plant Physiology. https://doi.org/10.1104/pp.19.00980

o Jackson MDB, Duran-Nebreda S, Kierzkowski D, Strauss S, Xu H, Landrein B, Hamant O, Smith RS, Johnston IG, Bassel GW (2019) Global Topological Order Emerges through Local Mechanical Control of Cell Divisions in the Arabidopsis Shoot Apical Meristem. Cell Systems. https://doi.org/10.1016/j.cels.2018.12.009

o Gruel J, Deichmann J, Landrein B, Hitchcock T, Jönsson H (2018) The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches. NPJ Syst Biol Appl. https://doi.org/10.1038/s41540-018-0072-1

o Gonneau M, Desprez T, Martin M, Doblas VG, Bacete L, Miart F, Sormani R, Hématy K, Renou J, Landrein B, Murphy E, Van De Cotte B, Vernhettes S, De Smet I, Höfte H (2018) Receptor Kinase THESEUS1 Is a Rapid Alkalinization Factor 34 Receptor in Arabidopsis. Current Biology. https://doi.org/10.1016/j.cub.2018.05.075

o Fal K, Landrein B, Hamant O (2016) Interplay between miRNA regulation and mechanical stress for CUC gene expression at the shoot apical meristem. Plant Signal Behav. https://doi.org/10.1080/15592324.2015.1127497

o Willis L, Refahi Y, Wightman R, Landrein B, Teles J, Huang KC, Meyerowitz EM, Jönsson H (2016) Cell size and growth regulation in the Arabidopsis thaliana apical stem cell niche. PNAS. https://doi.org/10.1073/pnas.1616768113

o Uyttewaal M, Burian A, Alim K, Landrein B, Borowska-Wykręt D, Dedieu A, Peaucelle A, Ludynia M, Traas J, Boudaoud A, Kwiatkowska D, Hamant O (2012) Mechanical stress acts via katanin to amplify differences in growth rate between adjacent cells in Arabidopsis. Cell. https://doi.org/10.1016/j.cell.2012.02.048

Reviews :
o Ali O, Cheddadi I, Landrein B, Long Y (2022) Revisiting the relationship between turgor pressure and plant cell growth. New Phytologist. https://doi.org/10.1111/nph.18683

o Lopes FL, Galvan-Ampudia C*, Landrein B* (2021) WUSCHEL in the shoot apical meristem, old player, new tricks. J Exp Bot. https://doi.org/10.1093/jxb/eraa572

o Landrein B, Ingram G. (2019) Connected through the force : mechanical signals in plant development. J Exp Bot. https://doi.org/10.1093/jxb/erz103

o Robinson S, Burian A, Couturier E, Landrein B, Louveaux M, Neumann ED, Peaucelle A, Weber A, Nakayama N. (2013) Mechanical control of morphogenesis at the shoot apex. J Exp Bot. https://doi.org/10.1093/jxb/ert199

o Landrein B, Hamant O. (2013) How mechanical stress controls microtubule behavior and morphogenesis in plants : history, experiments and revisited theories. Plant J. https://doi.org/10.1111/tpj.12188

o Bringmann M, Landrein B, Schudoma C, Hamant O, Hauser MT, Persson S. (2012) Cracking the elusive alignment hypothesis : the microtubule-cellulose synthase nexus unraveled. Trends Plant Sci. https://doi.org/10.1016/j.tplants.2012.06.003

Book chapters :
o Formosa-Jordan P, Landrein B. (2023) Quantifying Gene Expression Domains in Plant Shoot Apical Meristems. Methods Mol Biol. https://doi.org/10.1007/978-1-0716-3299-4_25

o Landrein B and Vernoux T. (2014) Auxin, chief architect of the shoot Apex. Springer Book, Auxin and its role in plant development. https://doi.org/10.1007/978-3-7091-1526-8_10

Oral presentations
2024 : Invited speaker at 7th Physics and Biological Systems conference (Univ. Paris Saclay, France)
2024 : Invited speaker at ISSER/ENS symposium (ENS de Lyon, France)
2023 : Invited speaker at MIFOBIO, session : MechanoBiology (Presqu’île de Giens, France)
2023 : Invited speaker at the workshop of the Newton Gateway to Mathematics : Walls across Kingdoms : Mechanics, Growth and Function of Cell Walls (Cambridge, UK)
2023 : Selected speaker at the XVIth Plant Cell Wall Meeting (Malaga, Spain)
2022 : Selected speaker at the Xth International Plant Biomechanics conference (Lyon, France)
2022 : Invited speaker at the Instituto de Hortofruticultura Subtropical y Mediterránea (University of Malaga, Spain)
2022 : Invited speaker at the online seminar series of Saclay Plant Sciences (France)
2022 : Invited speaker at the 4th Mechanobiology Symposium : Mechanics and Metabolism of the Center for Engineering Mechanobiology (CEMB, USA, Online)
2021 : Invited speaker at the Mechanobiology Meeting of the Belgium Society of Cell and Developmental Biology (BSCDB, Belgium)
2021 : Invited speaker at the Cell & Tissue Hydraulics Mini-Symposium of the Mechanobiology Institute of Singapore (Singapore, Online)
2016 : Short talk at the Sainsbury symposium : Plant Induced Development (UK)
2014 : Invited speaker for the joint conference of the French and German Societies of Developmental Biology (Germany)
2013 : Shared talk with Olivier Hamant in the 2013 FASEB conference “Mechanisms of Plant Development” (USA)
2013 : Invited speaker for the 2013 conference of the PhD school of plant Biology of Paris (France)
2013 : Speaker in the 2013 conference of the PhD school of Molecular Biology of Lyon (France)
2012 : Short talk in the 7th International Plant Biomechanics conference (France)

Poster presentations
2018 : Gordon Research Conference : Plant Molecular Biology (USA)
2016 : Sainsbury Symposium : Plant Induced Development (UK)
2013 : FASEB conference “Mechanisms of Plant Development” (USA)
2013 : 1st French Microtubule Network conference (France)
2012 : 7th International Plant Biomechanics conference (France)