Transport across nanopores and nanofluidics
Transport across nanopores
Fabien Montel,Cendrine Moskalenko,Martin Castelnovo,
We investigate the transport properties of biological molecules (DNA) or complexes (viral capsids) across synthetic and biological nanopores within controlled environments. The nuclear pore complex is the gateway for molecular traffic bewteen the nucleus and the cytoplasm. Some viruses involved in gene therapy (AAV) or pathology generator (HBV) are transported through this nanopore. Based on the growing evidence on the geometrical and mehcanical plasticity of the nuclear pore we investigate the ability of these viruses to deform and adpat the structure of the pore. In collaboration with IGFL, CIRI and IBCP, we use AFM to probe and model the geometric and mechanical changes induced by the virus entry under physciological conditions and in real time.
Nanofluidic
Our research focuses on ionic memory phenomena for computing applications. We develop solid-state nanofluidic devices using advanced nanofabrication techniques and characterize memory effects through direct imaging approaches that combine optics and electrokinetics. Ultimately, we aim to build integrated nanofluidic circuits for non-electronic data processing.