CURRICULUM VITAE

Education

1992-1995:  Ecole Polytechnique (Palaiseau Paris France)

1995-1996:  Diplôme d'Etude Approfondie in Molecular and Cellular Biology from Pasteur University (Strasbourg).

Research topic: Cloning of the gene responsible for spinocerebellar ataxia type 2. Mentor: Jean-Louis Mandel, IGBMC.

1996-2000: Ph.D. in Molecular and Cellular Biology.

Title: Neurodegenerative diseases due to polyglutamine expansions: identification of two causative genes and development of animal models. Mentor: Jean-Louis Mandel, IGBMC. Distinction: Felicitations du jury and award from ADRERUS.

2001-2002: Postdoc at the Fred Hutchinson Cancer Research Center, Howard Hughes Medical Institute, Seattle, U.S.A. Fellowship from the Human Frontier Science Program.

Research topic: Genetics of genome expression regulation in yeast. Mentor: Leonid Kruglyak.

2003:  Hired at Centre National de la Recherche Scientifique (CNRS) and joins the group of Jean-Marie Francois in Toulouse.

2005: Launches the group "Genetics of Intra-Species Variations" at Ecole Normale Superieure de Lyon. Supported by a Young Investigator grant (ATIP) from CNRS.

2007: Obtains degree "HDR", a frenchy-french post-Ph.D. diploma allowing to supervise research programs.

2007-2010: Also consultant for Lesaffre International

2011: Promoted as CNRS Director of Research (DR2)

Awards

2002: Human Frontier Long Term Fellowship Award

2008: Paul Langevin award from the French Academy of Science

2009: Bronze Medal award from CNRS

2011: Starting (Consolidator) Independent Grant from the European Research Council (ERC)

Scientific Publications

Listed are publications appearing in peer-review journals only, and anterior to the date of group creation. For more recent publications, please go to the list of group publications.

Imbert G*; Saudou F*; Yvert G*; Devys D; Trottier Y; Garnier JM; Weber C; Mandel JL; Cancel G*; Abbas N; Durr A; Didierjean O; Stevanin G; Agid Y; Brice A. Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. Nature Genetics  1996 14:285-91. ( *: equal contribution)

Cancel G; Durr A; Didierjean O; Imbert G; Burk K; Lezin A; Belal S; Benomar A; Abada-Bendib M; Vial C; Guimaraes J; Chneiweiss H; Stevanin G; Yvert G; Abbas N; Saudou F; Lebre AS; Yahyaoui M; Hentati F; Vernant JC; Klockgether T; Mandel JL; Agid Y and  Brice A. Molecular and clinical correlations in spinocerebellar ataxia 2: a study of 32 families. Human Molecular Genetics  1997 6:709-15

David G; Abbas N; Stevanin G; Durr A; Yvert G; Cancel G; Weber C; Imbert G; Saudou F; Antoniou E; Drabkin H; Gemmill R; Giunti P; Benomar A; Wood N; Ruberg M; Agid Y; Mandel JL and Brice A. Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion. Nature Genetics 1997 17:65-70.

Wittekindt O; Jauch A; Burgert E; Schärer L; Holtgreve-Grez H; Yvert G; Imbert G; Zimmer J; Hoehe M; Macher J-P; Chiaroni P; Van Calker D; Crocq M-A; and morris-Rosendahl D. The human small conductance calcium-regulated potassium channel gene (hSKCa3) contains two CAG repeats in exon 1, is on chromosome 1q21.3, and shows a possible association with schizophrenia. Neurogenetics  1998 1: 259-265.

Yvert G and Mandel J-L. Variation on a trinucleotide theme. Nature Medicine. 1999 5:383-384.

Lindenberg KS, Yvert G, Muller K, and Landwehrmeyer GB. Expression analysis of ataxin-7 mRNA and protein in human brain: evidence for widespread distribution and focal protein accumulation. Brain Pathology 2000 10:385-94.

Yvert G, Lindenberg KS, Picaud S, Landwehrmeyer GB, Sahel J-A and Mandel J-L. Expanded polyglutamines induce neuroidegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. Human Molecular Genetics 2000  9:2491-2506.

Cancel G, Duyckaerts C, Holmberg M, Zander C, Yvert G, Lebre AS, Ruberg M, Faucheux B, Agid Y, Hirsch E, Brice A. Distribution of ataxin-7 in normal human brain and retina. Brain 2000 123: 2519-30.

Yvert G, Lindenberg KS, Devys D, Helmlinger D, Landwehrmeyer GB and Mandel J-L. SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types. Human Molecular Genetics 2001  10:1679-1692.

Takahashi J, Fujigasaki H, Zander C, El Hachimi KH, Stevanin G, Durr A, Lebre AS, Yvert G, Trottier Y, The H, Hauw JJ, Duyckaerts C, Brice A. Two populations of neuronal intranuclear inclusions in SCA7 differ in size and promyelocytic leukaemia protein content. Brain 2002 125:1534-43.

Helmlinger D, Yvert G, Picaud S, Merienne K, Sahel J, Mandel JL, Devys D. Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice. Human Molecular Genetics 2002 11:3351-3359.

Brem RB*, Yvert G*, Clinton R, and Kruglyak L. Genetic dissection of transcriptional regulation in budding yeast. Science 2002 296:752-755. ( *: equal contribution)

Yvert G, Brem RB, Whittle J, Akey JM, Foss EJ, Smith EN, Mackelprang R, and Kruglyak L. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nature Genetics 2003 35:57-64.

Helmlinger D, Abou-Sleymane G, Yvert G, Rousseau S, Weber C, Trottier Y, Mandel JL and Devys D. Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model. Journal of Neuroscience, 2004 24(8):1881-1887.

Ronald J, Akey JM, Whittle J, Yvert G and Kruglyak L. Simultaneous genotyping, gene expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Research, 2005 15:284-291.

For more recent publications, please go to the list of group publications.