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Laboratoire de Biologie et Modélisation de la Cellule - UMR 5239 - Inserm 1293

The LBMC is an experimental biology laboratory hosted at ENS de Lyon in a multidisciplinary scientific environment. The laboratory's main subject of study is the cell, which is the most fundamental unit of life.

The 15 research teams aim at integrating diverse aspects of cell life such as proliferation, differentation, and interaction with cellular environment in a normal or pathogenic context. The fundamental research pursued in the laboratory relies on expertise in cellular and molecular biology and integrates interdisciplinary approaches in (bio)computing, (bio)physics and (bio)mathematics.

More details here.

Follow us on Twitter @Lyon_LBMC

Last publications
2022 Dai Y & al, EMBO Rep Structural mechanism underpinning Thermus oshimai (...) G (...)
2022 Mom R & al, Biomolecules A Perspective for Ménière's Disease: In Silico (...) M (...)
2022 Khatri D & al, Mol Biol Cell Evolutionary divergence of anaphase spindle (...) C (...)
2022 Caron M & al, Life Sci Alliance Loss of SET1/COMPASS methyltransferase activity (...) C (...)
2022 Hatat A & al, Mol Oncol Altered splicing of ATG16-L1 mediates acquired (...) D (...)
2022 Terrone S & al, Nucleic Acids Res RNA helicase-dependent gene looping impacts (...) D (...)
2022 Dincã D & al, Nat Commun Myotonic dystrophy RNA toxicity alters (...) B (...)
2022 Cluet D & al, Chembiochem Titration of Apparent In-Cellula Affinities of (...) A (...)
2022 Torres-Campana D & al, PLoS Genet Three classes of epigenomic regulators converge (...) T (...)
2022 Belokopytova P & al, Nucleic Acids Res 3DGenBench: a web-server to benchmark (...) M (...)
2022 Hennion M & al, Methods Mol Biol FORK-seq: Single-Molecule Profiling of DNA (...) M (...)
2022 Theulot B & al, Nat Commun Genome-wide mapping of individual replication (...) L (...)
Genome mechanics
Homologous recombination is a universal DNA break repair pathway involved in a variety of (...) Read more
Physical Biology of Chromatin
In close connection with experimental biology, our research addresses generic or specific (...) Read more
Epigenetics and Zygote Formation
The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual (...) Read more
RNA metabolism in immunity and infection (RMI2)
We are interested in post-transcriptional control mechanisms that regulate gene expression in cells (...) Read more
Genetic Complexity of Living Systems
Our research group is interested in the fundamental genetic mechanisms underlying inter-individual (...) Read more
Epigenetic regulation of cell identity and environmental stress responses
We are interested in understanding the role of conserved chromatin marks in the maintenance of (...) Read more
Evolutionary Cell Biology in Nematodes
We compare basic cellular functions between closely related species. We ask to what extent the (...) Read more
Regulated Cell Death and Genetics of Neurodegeneration
The general goal of our lab is to understand the mechanisms of cell death, ER stress, autophagy and (...) Read more
Quantitative regulatory genomics
Why are individuals different? We address this fundamental question by studying both genetic and (...) Read more
Regulation of Genome Architecture and Dynamics of Splicing (ReGArDS)
Our team is interested in the regulation of alternative splicing, the main process allowing to (...) Read more
Comparative and Integrative Genomics of Organ Development
We compare genomes and transcriptomes to highlight general rules about the development and/or the (...) Read more
Posttranscriptional Regulation in Infection and Oncogenesis
Our main research interest is to decipher the molecular mechanisms underlying oncogenesis, with a (...) Read more
Epithelial differentiation and morphogenesis in Drosophila
Read more
Systems Biology of Decision Making
The molecular mechanisms controlling decision making at the cellular level between self-renewal and (...) Read more
Chromatin Dynamics in Mitotic Chromosome Assembly
The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The (...) Read more
Oct 07, 2022 Specificity and function of Argonaute protein-mediated pathways
Oct 14, 2022 Different contributions of epithelium and mesenchyme in patterning of the skin
Oct 17, 2022 Mechanism of homologous recombination: The roles of the Rad54 and Rdh54/Tid1 motor proteins
Oct 18, 2022 Deep mutational scanning of entire human protein interaction domain families
Upcoming thesis defenses