Wednesday, October 31, 2018

08:30 am - 09:00 am Welcome
09:00 am - 09:40 am Chair: Daniel KAHN, Lyon, France
Ines THIELE, Esch-sur-Alzette, Luxembourg
Personalized whole-body models integrate metabolism, physiology, and the gut microbiome
09:40 am - 10:20 am Chair: Daniel KAHN, Lyon, France
Uwe SAUER, Zurich, Switzerland
Metabolic coordination through metabolite-protein interactions
10:20 am - 10:50 am Coffee break
10:50 am - 12:30 pm Three parallel sessions

Methodological developments for Systems Biology B

Chair: Mustafa KHAMMASH, Basel, Switzerland


Satya SAMAL, Aachen, Germany 
10:50 am - 11:10 am
Sensitive parameters and tipping points of biochemical networks with potential applications in precision medicine

Anne POUPON, Nouzilly, France 
11:10 am - 11:30 am      
Parameter estimation in dynamical models for systems biology – the delicate balance between identifiability and predictivity

Ozgur AKMAN, Exeter, United Kingdom
11:30 am - 11:50 am    
The parameter explosion problem: extending the scope of GRN modelling by combining reduced models with evolutionary computation

Martial GUILLAUD, Vancouver, Canada
11:50 am - 12:10 pm
Hyperspectral cell sociology analysis of histological specimens

Serge PELET, Lausanne, Switzerland
12:10 pm - 12:30 pm
Dynamic single cell analysis of a cell fate decision system

Systems Medicine B

Chair: Jacqueline MARVEL, Lyon, France


Teresa LEHNERT, Jena, Germany 
10:50 am - 11:10 am
Characterization of different sepsis phases by virtual infection modeling of the innate immune response in human whole blood

Anna MEDYUKHINA, Jena, Germany
11:10 am - 11:30 am  
Automated image analysis of mast cell - dendritic cell interactions reveals weapon transfer in immune system

Chloe AUDEBERT, Villeurbanne, France
11:30 am - 11:50 am 
Non-linear mixed effects models to study inter-individual variability in CD8 T cell immune responses in mice.

Chen-Hsiang YEANG, Taipei, Taiwan 
11:50 am - 12:10 pm       
Modelling bistable tumour population dynamics to design effective treatment strategies

Marcel SCHILLING, Heidelberg, Germany
12:10 pm - 12:30 pm             
The complex life of Smad isoforms determines gene expression in hepatocellular carcinoma

Modelling Networks and Circuits B

Chair: Ina KOCH, Frankfurt, Germany


Jonas BÉAL, Paris, France
10:50 am - 11:10 am        
Instantiation of patient-specific logical models with multi-omics data allows clinical stratification of patients

Oleksii RUKHLENKO, Dublin, Ireland
11:10 am - 11:30 am        
Structure-based kinetic modelling reveals kinase inhibitor combinations to overcome oncogenic RAS signalling

Yaroslav NIKOLAEV, Zurich, Switzerland
11:30 am - 11:50 am 
Systems NMR: simultaneous quantitative monitoring of RNA, protein, and metabolite dynamics for biomolecular network analysis

Daniel JOST, La Tronche, France
11:50 am - 12:10 pm             
Assigning function to natural allelic variation via dynamic modeling of gene network induction

Ulysse HERBACH, Lyon, France 
12:10 pm - 12:30 pm   
Inferring gene regulatory networks using single-cell data: from mechanistic modelling to statistics

12:30 pm - 02:00 pm Lunch
02:00 pm - 03:30 pm Poster session
03:30 pm - 04:00 pm Coffee break
04:00 pm - 05:40 pm Three parallel sessions

Methodological developments for Systems Biology C

Chair: Anne POUPON, Nouzilly, France


Laurent GUYON, Grenoble, France
04:00 pm - 04:20 pm       
miRNA selection using miRNA network a priori showed improved reliability and identify functionally related miRNAs

Andras GYORGY, Abu Dhabi, United Arab Emirates
04:20 pm - 04:40 pm
Optimal part characterization with shared cellular resources

Arthur GOLDBERG, New York, United States
04:40 pm - 05:00 pm       
A multialgorithmic simulator for whole-cell biochemical models

Silas Boye NISSEN, Copenhagen, Danmark
05:00 pm - 05:20 pm
Four simple rules that are sufficient to generate the mammalian blastocyst 

Jörn STARRUSS, Dresden, Germany 
05:20 pm - 05:40 pm      
Morpheus: a user-friendly and extensible simulation framework for declarative modelling in multiscale and multicellular systems biology

Systems Medicine C

Chair: Maria Manuela NOGUEIRA, Lyon, France


Fortunato BIANCONI, Perugia, Italy
04:00 pm - 04:20 pm     
Machine learning pipeline for pathways analysis with reverse phase microarray data of non-small cell lung cancer cell lines and different drugs

Michiel ADRIAENS, Maastricht, Netherlands
04:20 pm - 04:40 pm 
Putting the squeeze on RNA-seq data: mapping individualized genetic and epigenetic regulation in complex diseases

Avijit PODDER, New Delhi, India
04:40 pm - 05:00 pm                     
Therapeutic understanding of human dopaminergic system in neurological diseases - a systems biology approach

Pedro MENDES, Farmington, United States
05:00 pm - 05:20 pm
Transforming physiological models from mice to humans - the case of iron homeostasis.

Dominik LUTTER, Neuherberg, Germany
05:20 pm - 05:40 pm
A circadian metabolomics atlas of the body under chronic nutrient stress

Modelling Networks and Circuits C

Chair: Ralf STEUER, Berlin, Germany

Niklas KORSBO, Cambridge, United Kingdom
04:20 pm - 04:40 pm  
Precise adaptation in stem cell control

Martin  ZAUSER, Heidelberg, Germany 
04:40 pm - 05:00 pm  
Automated image analysis and modeling of calcium waves in plant roots

Jian-Geng CHIOU, Durham, United States
05:00 pm - 05:20 pm           
Principles that govern competition or co-existence in Rho-GTPase driven polarization in the budding yeast

Atsushi MOCHIZUKI, Kyoto, Japan
05:20 pm - 05:40 pm            
Controlling cell fate specification system based on network structure

05:50 pm - 06:30 pm Chair: Annamaria CARUSI, Sheffield, UK
Barbara PRAINSACK, Vienna, Austria
Is precision medicine “open”?