Directory
Mike ORGAN
| When |
Feb 22, 2018 à 10:30 AM |
|---|---|
| Where |
Salle des thèses |
Translating Organometallic Properties Into High-Performance Catalysts For Organic Synthesis
Considerable effort for almost half a century has been devoted to understanding how ligand steric and electronic properties modulate the reactivity of a metal centre in a large number of catalytic processes. This is confounded by the fact that many of these transformations have two or more steps in their catalytic cycles, which may mean that a favourable attribute in one step may act to disfavour another step. Many groups have worked diligently to develop methods to probe and grade ligand properties such that they can be used in, ideally, a predictive fashion to guide the development of new catalysts. In this presentation our approach to rational ligand design in cross-coupling applications will be discussed and how this approach has been used to improve catalyst performance. In particular, time will be dedicated to the discussion of 1) the incorporation of secondary alkyl centres without isomerization and 2) in the introduction of primary amines without over arylation.