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Physical Biology of Chromatin - D. Jost
In close connection with experimental biology, our research addresses generic or specific biological questions on chromatin and gene regulation by developing physical and computational models. Particularly, we focus on the spatio-temporal dynamics of eukaryotic chromosomes. Our research tackles important questions regarding the coupling between 3D structure and functions of chromatin. Our objective is to provide some universal principles driving chromatin folding and regulation, while contextualizing our approaches to fundamental, specific problems of 3D genomics.
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Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The profound reorganisation of long chromatin fibres into rod-shaped chromosomes in mitosis is an iconic example of this structural dynamics. The main goal of our research is to understand the cellular mechanisms that take place at the chromatin level for the assembly of segregation-competent mitotic chromosomes. We use the fission yeast Schizosaccharomyces pombe and human cultured cells as model systems.
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Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon
We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs.
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Our research group is interested in the fundamental genetic mechanisms underlying inter-individual phenotypic differences. We wish to better understand why some individuals are more likely than others to develop specific traits.
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Condensin in the context of chromatin - P. Bernard
Determining (1) the mechanisms that make chromatin suitable for condensin action in vivo,(2) the role of condensin at telomeres, and (3) the link between condensin and S phase.
Located in Teams / Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
Evolutionary Cell Biology in Nematodes - M. Delattre
We compare basic cellular functions between closely related species. We ask to what extent the underlying mechanisms have evolved, at the molecular and the biophysical level. We explore which parameters of the system are constraining change or building in innovation. We use free-living nematodes as a study system because they offer many experimental advantages
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RNA metabolism in immunity and infection (RMI2) - E. Ricci
We are interested in post-transcriptional control mechanisms that regulate gene expression in cells of the immune system and during pathogen infections. Through the use of high-throughput sequencing and biochemical approaches we aim at identifying new regulatory layers that govern immune cell activation and host-pathogen interactions.
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Presentation
Comparative and Integrative Genomics of Organ Development - CIGOGNE - S.Pantalacci/M. Sémon
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Quantitative regulatory genomics - Mirko Francesconi
Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time to contribute to phenotypic variation.
Located in Teams
Quantitative regulatory genomics - M. Francesconi
Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time to contribute to phenotypic variation.
Located in Teams