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Genome mechanics - A. Piazza

DNA is a busy molecule teeming with a zoo of static binders and molecular motors. DNA's informational, structural, and organizational properties are exploited by, or regulate, multiple protein-mediated activities. Our goal is to determine the interplay between the active 3D organization of DNA in the nucleus and the molecular process of target search by protein in DNA. We study this general question in the particular case of the repair of DNA break by homologous recombination. Homologous recombination is a universal DNA break repair pathway that uses an intact DNA molecule as a repair template, which has to be identified in the whole genome by the broken molecule. We study the basic mechanism of this search for homology in both somatic cells and in meiosis using budding yeast as a model organism.