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Ana LOSADA - Centro Nacional de Investigaciones Oncológica, Madrid

Specific contributions of variant cohesin complexes to genome folding
When May 24, 2019
from 11:00 AM to 12:00 PM
Contact Name Equipe Bernard - Salle Condorcet (1 place de l'école)
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Cohesin is one of the three SMC complexes present in eukaryotic cells. Although it was initially identified for its role in sister chromatid cohesion, more recent studies have shown that cohesin plays also a central role in the spatial organization of the genome. Two variant cohesin complexes containing SMC1, SMC3, RAD21 and either STAG/SA1 (cohesin-SA1) or STAG/SA2 (cohesin-SA2) are present in all cell types of vertebrate organisms. In my talk, I will describe recent efforts in my group to understand the specific functions of these two variant complexes, with particular emphasis on their roles in genome organization and gene regulation.