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Paolo ANNIBALE, Max Delbrück Center for Molecular Medicine in the Helmholtz Association - BERLIN

Quantitative fluorescence spectroscopy methods at the single cell level
When Feb 14, 2020
from 10:00 AM to 12:00 PM
Contact Name Salle des Thèses, Equipe Gandrillon
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Fluorescence microscopy methods can be employed to quantitatively monitor signaling within living cells. In particular, out of equilibrium fluctuations of the photon counts arising from diffusing fluorescently labeled molecules can be used to extract precise information on the dynamics as well as oligomerisation state of specific molecules. We will provide in this seminar a brief introduction to the biophysical foundation of these approaches before offering a tour over three state of the art applications: (i) Oligomerisation of G Protein Coupled Receptors, (ii) Quantification of non canonical amino acid labeling and (iii) dynamics of nuclear receptors at endogenous expression levels

Contact : O. Gandrillon / G. Benoît