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Systems biology of signaling and developmental cellular processes

Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon

We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs. Read more

Epigenetics and Zygote Formation - B. Loppin

The formation of a diploid zygote from two highly different gametes is a critical aspect of sexual reproduction in animals. Notably, the transmission of the paternal genome implies unique chromatin reorganization events that take (...) Read more

Epithelial differentiation and morphogenesis in Drosophila - M. Grammont

Epithelia form a vital part of all our tissues and organs. The adhesive properties of these cellular sheets and the ability of their component cells to change shape and/or to move are essential to generate a large number of (...) Read more

Plasticity and Evolution of the Cell Division - M. Delattre

The cell is a level of biological organisation that has been poorly explored from an evolutionary perspective. How do cellular mechanisms evolve? What is the extent of possible solutions that have been retained across evolution (...) Read more

Epigenetic regulation during development - F. Palladino

We are interested in understanding the role of conserved chromatin marks in the maintenance of germline identity and the response to environmental stress. To adress these questions, we are using C. elegans as a model organism. (...) Read more

Structure and Interactions of Molecular Biosystems - M. Spichty

We apply atomic-level computer simulations and molecular and cellular biology experiments to gain insights into the dynamic structure of proteins and their interactions in living cells. The main goal is to understand the factors (...) Read more

Systems Biology of Decision Making - O. Gandrillon

The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms (...) Read more

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