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Aurora B and condensin are dispensable for chromosome arm and telomere separation during meiosis II.

Julien Berthezene, Céline Reyes, Tong Li, Stéphane Coulon, Pascal Bernard, Yannick Gachet, and Sylvie Tournier (2020)

Mol Biol Cell, 31(9):889-905.

In mitosis, while the importance of kinetochore (KT)-microtubule (MT) attachment hasbeen known for many years, increasing evidence suggests that telomere dysfunctionsalso perturb chromosome segregation by contributing to the formation of chromatinbridges at anaphase. Recent evidence suggests that Aurora B kinase ensures properchromosome segregation during mitosis not only by controlling KT-MT attachment butalso by regulating telomere and chromosome arm separation. However, whether and howAurora B governs telomere separation during meiosis has remained unknown. Here, weshow that fission yeast Aurora B localizes at telomeres during meiosis I andpromotes telomere separation independently of the meiotic cohesin Rec8. In meiosisII, Aurora B controls KT-MT attachment but appears dispensable for telomere andchromosome arm separation. Likewise, condensin activity is nonessential in meiosisII for telomere and chromosome arm separation. Thus, in meiosis, the requirementsfor Aurora B are distinct at centromeres and telomeres, illustrating the criticaldifferences in the control of chromosome segregation between mitosis and meiosis II.

 
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