Aller au contenu. | Aller à la navigation

Outils personnels

Navigation
Vous êtes ici : Accueil / Équipes / Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon / Publications / Monoallelic expression and tissue specificity are associated with high crossover rates.

Monoallelic expression and tissue specificity are associated with high crossover rates.

Anamaria Necsulea, Marie Semon, Laurent Duret, and Laurence D Hurst (2009)

Trends Genet, 25(12):519-22.

What determines the recombination rate of a gene? Following the observation that, in humans, imprinted genes have unusually high recombination levels, we ask whether increased recombination is seen for other monoallelically expressed genes and, more generally, how transcriptional properties relate to recombination. We find that monoallelically expressed genes do have high crossover rates and discover a striking negative correlation between within-gene crossover rate and expression breadth. We hypothesise that these findings are possibly symptomatic of a more general, adverse relationship between recombination and transcription in the human genome.

 
automatic medline import

Actions sur le document