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Comparing organ development with transcriptomes
Developing organs are far from being a mass of identical cells. The expression of thousands of genes is regulated, which modulates the behavior and fate of complex cell populations on top of distinguishing them.
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Principal component analysis is a useful tool to compare transcriptome timeseries |
We show that comparing transcriptomes of different molar germs (lower/upper molar), different molar parts (buccal/lingual) and different species yield insights in the nature and abundance of cell populations throughout development. These are precious informations to understand how development results in different final morphologies and differs between species.
See our paper in Genome Biology and the accompagnying dispatch by Maayan Baron and Itai Yanai. See also a short advertisement from the CNRS/INSB webpage (in french).
People involved in the team: Coraline Petit; Anne Lambert (Past member)
Collaborations: Laurent Guéguen, Université Lyon 1
