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Vous êtes ici : Accueil / Équipes / Métabolisme des ARNs au cours de la réponse immunitaire et de l’infection - E. Ricci / Publications / The 3' untranslated region of the Andes hantavirus small mRNA functionally replaces the poly(A) tail and stimulates cap-dependent translation initiation from the viral mRNA.

The 3' untranslated region of the Andes hantavirus small mRNA functionally replaces the poly(A) tail and stimulates cap-dependent translation initiation from the viral mRNA.

Jorge Vera-Otarola, Ricardo Soto-Rifo, Emiliano P Ricci, Theophile Ohlmann, Jean-Luc Darlix, and Marcelo Lopez-Lastra (2010)

J Virol, 84(19):10420-4.

In the process of translation of eukaryotic mRNAs, the 5' cap and the 3' poly(A)tail interact synergistically to stimulate protein synthesis. Unlike its cellular counterparts, the small mRNA (SmRNA) of Andes hantavirus (ANDV), a member of theBunyaviridae, lacks a 3' poly(A) tail. Here we report that the 3' untranslated region (3'UTR) of the ANDV SmRNA functionally replaces a poly(A) tail and synergistically stimulates cap-dependent translation initiation from the viral mRNA. Stimulation of translation by the 3'UTR of the ANDV SmRNA was found to be independent of viral proteins and of host poly(A)-binding protein.

 
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