Few words about the LBMC

The LBMC is an experimental biology laboratory hosted at ENS de Lyon in a multidisciplinary scientific environment. The laboratory's main subject of study is the cell, which is the most fundamental unit of life.

The laboratory's research teams aim at integrating diverse aspects of cell life such as proliferation, differentation, and interaction with cellular environment in a normal or pathogenic context.

The research performed at LBMC involves :

• a wide diversity of model organisms such as budding and fission yeast, nematodes, insects (drosophila and crickets), rodents, as well as avian, murine and human cells.
• a wide diversity of cell biology approaches from cell culture to microscopy thanks to an advanced technology facility called Platim.
• a wide diversity of molecular biology approaches from the generation of genetic models (using CRISPR/Cas9 technology for instance) to the generation of large datasets (in particular for genomics and transcriptomics).

The fundamental research pursued in the laboratory relies on expertise in cellular and molecular biology and integrates interdisciplinary approaches in (bio)computing, (bio)physics and (bio)mathematics. We are convinced that the integration of these fields to our research is essential and we seek to promote such interdisciplinary work.

Biomathematics

The LBMC has been very active developing collaborations with mathematicians, computer scientists and statisticians, who are now given the opportunity to develop their own methodological research within the laboratory to be at the core of current challenges in computational biology. This line of research is being developed along two methodological lines: Dynamical Modelling and AI / Machine Learning.

Biophysics

Many biophysical approaches are now routinely incorporated into our research programs: from the use of advanced experimental physical instruments like microfluidics to the development of biophysical models to capture the intrinsic physical nature of biological processes and biomolecules.

Biocomputing

To cope with the amount of information produced by modern biological experiment we routinely use AI and Machine Learning algorithms at the LBMC. We also develope dedicated machine learning models for the data analysis of original experiments produced at the lab by various genomic sequencing and imaging technologies.

One of the strength of ENS de Lyon is the interdisciplinarity of its teaching. Many teachers and reasearcher at LBMC embrace this trend towards more interdisciplinarity between biology/maths/physics/info and beyond. Within the biology department, we actively participate in the new teaching curriculums (2022-) from L3 to M2. Some of us are also involved in the « Complex Systems » M2 headed by IXXI.