FUNCTIONS OF THE RETROMER in plant development

Pollen-PISTIL interaction

LIPID SIGNALING

PEOPLE

PUBLICATIONS

POSITIONS & INTERNSHIPS

CONTACT

LINKS

RESOURCES & materials:

FUNCTIONS OF THE RETROMER in plant development

Endocytosis and protein trafficking have recently emerged as major players in the regulation of signaling pathways in various eukaryotic model systems, including plants. The internalization of plasma membrane receptors and the paths they take once inside the cell actively control the duration, amplitude and specificity of signaling.

The retromer is conserved from yeast to human, including plants, and is involved in the recycling of membrane receptors that mediate the transport of vacuolar/lysosomal hydrolases. Interestingly, new functions are being discovered for the retromer, such as an essential role in mouse embryo development or in WNT-dependent signaling pathways that regulate various developmental processes in Caenorhabditis elegans, flies and mammals. We recently found that the plant retromer complex acts in cell polarity and demonstrated its key role in embryo development and organogenesis in Arabidopsis thaliana.

We now want to address :

- What are the cellular and developmental pathways regulated by the plant retromer?

-What are the molecular mechanisms by which the retromer controls intracellular trafficking and cell signaling?

- What are the functions of the retromer in receptor kinase signaling?

ORCHESTRATING CELLULAR TRAFFICKING TO CONTROL SIGNALING

SELECTED publications

Thazar-Poulot N, Miquel M, Fobis-Loisy I, Gaude T. 2015. Peroxisome extensions deliver the Arabidopsis SDP1 lipase to oil bodies. PNAS. Mar 31;112(13):4158-63.

Zelazny E, Santambrogio M, Pourcher M, Chambrier P, Berne-Dedieu A, Fobis-Loisy I, Miege C, Jaillais Y, Gaude T. 2013 Mechanisms governing the endosomal membrane recruitment of the core retromer in Arabidopsis. J Biol Chem Mar 29;288(13):8815-25

Pourcher, M., Thazar, N., Santambrogio, M., Thierry, A.-M., Fobis-Loisy, I., Miège, C., Jaillais Y, and Gaude, T. 2010 Distinct functions of retromer subcomplexes in plant development and protein sorting. Plant Cell, 12, 3980-91

Jaillais Y and Gaude T. 2008 Plant Cell Polarity: Sterols Enter into Action after Cytokinesis. Developmental Cell, 14, 318-320

Jaillais Y, Fobis-Loisy I, Miège C, Gaude T. 2008 Evidence for a sorting endosome in Arabidopsis root cells. Plant Journal, 53, 237-247

Jaillais Y, Santambrogio M, Rozier F, Fobis-Loisy I, Miège C, Gaude T. 2007 The retromer protein VPS29 links cell polarity and organ initiation in plants. Cell, 130, 1057-1070

Jaillais Y, Fobis-Loisy I, Miège C, Rollin C, Gaude T. 2006 AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis. Nature, 443, 106-109

Vanoosthuyse V, Tichtinsky G, Dumas C, Gaude T, Cock JM. Interaction of calmodulin, a sorting nexin and kinase-associated protein phosphatase with the Brassica oleracea S locus receptor kinase. Plant Physiol. 2003 133:919-29.

Cell Signaling lab

RDP - ENS Lyon - 46 Allee d’italie

69364 Lyon cedex 07 - France

Web Site : Yvon Jaillais