-
Genetic Complexity of Living Systems - G. Yvert
-
Our research group is interested in the fundamental genetic mechanisms underlying inter-individual phenotypic differences. We wish to better understand why some individuals are more likely than others to develop specific traits.
Located in
Teams
-
Condensin in the context of chromatin - P. Bernard
-
Determining (1) the mechanisms that make chromatin suitable for condensin action in vivo,(2) the role of condensin at telomeres, and (3) the link between condensin and S phase.
Located in
Teams
/
Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
-
Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
-
The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The profound reorganisation of long chromatin fibres into rod-shaped chromosomes in mitosis is an iconic example of this structural dynamics. The main goal of our research is to understand the cellular mechanisms that take place at the chromatin level for the assembly of segregation-competent mitotic chromosomes. We use the fission yeast Schizosaccharomyces pombe and human cultured cells as model systems.
Located in
Teams
-
Regulation of Genome Architecture and Dynamics of Splicing (ReGArDS) - D. Auboeuf and C. Bourgeois
-
Our team is interested in the regulation of alternative splicing, the main process allowing to largely increase the functional diversity of proteins coded by a limited number of genes in higher organisms.
Located in
Teams
-
Systems Biology of Decision Making - O. Gandrillon
-
The molecular mechanisms controlling decision making at the cellular level between self-renewal and differentiation are still poorly understood. The central question of our group consists in understanding the molecular mechanisms controlling self-renewal and the alteration of these mechanisms in relation to the onset of cancer.
Located in
Teams
-
Presentation
-
Comparative and Integrative Genomics of Organ Development - CIGOGNE - S.Pantalacci/M. Sémon
Located in
Teams
-
Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon
-
We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs.
Located in
Teams
-
Quantitative regulatory genomics - Mirko Francesconi
-
Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time and how perception of ancestral environment contributes to phenotypic variation.
Located in
Teams
-
Quantitative regulatory genomics - M. Francesconi
-
Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time to contribute to phenotypic variation.
Located in
Teams
-
RNA metabolism in immunity and infection (RMI2) - E. Ricci
-
We are interested in post-transcriptional control mechanisms that regulate gene expression in cells of the immune system and during pathogen infections. Through the use of high-throughput sequencing and biochemical approaches we aim at identifying new regulatory layers that govern immune cell activation and host-pathogen interactions.
Located in
Teams
Directory