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Physical Biology of Chromatin - D. Jost
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In close connection with experimental biology, our research addresses generic or specific biological questions on chromatin and gene regulation by developing physical and computational models. Particularly, we focus on the spatio-temporal dynamics of eukaryotic chromosomes. Our research tackles important questions regarding the coupling between 3D structure and functions of chromatin. Our objective is to provide some universal principles driving chromatin folding and regulation, while contextualizing our approaches to fundamental, specific problems of 3D genomics.
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RNA metabolism in immunity and infection (RMI2) - E. Ricci
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We are interested in post-transcriptional control mechanisms that regulate gene expression in cells of the immune system and during pathogen infections. Through the use of high-throughput sequencing and biochemical approaches we aim at identifying new regulatory layers that govern immune cell activation and host-pathogen interactions.
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Welcome to the RMI2 lab
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RNA metabolism in immunity and infection (RMI2)
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Genetic Complexity of Living Systems - G. Yvert
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Our research group is interested in the fundamental genetic mechanisms underlying inter-individual phenotypic differences. We wish to better understand why some individuals are more likely than others to develop specific traits.
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Quantitative regulatory genomics - M. Francesconi
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Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time to contribute to phenotypic variation.
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Quantitative regulatory genomics - Mirko Francesconi
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Why are individuals different? We address this fundamental question by studying both genetic and non-genetic sources of phenotypic variation, using both genome-wide computational and experimental systems biology approaches in model organisms. In particular, we are interested in understanding how gene expression is regulated in space and time and how perception of ancestral environment contributes to phenotypic variation.
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Presentation
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Comparative and Integrative Genomics of Organ Development - CIGOGNE - S.Pantalacci/M. Sémon
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Regulation of Genome Architecture and Dynamics of Splicing (ReGArDS) - D. Auboeuf and C. Bourgeois
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Our team is interested in the regulation of alternative splicing, the main process allowing to largely increase the functional diversity of proteins coded by a limited number of genes in higher organisms.
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Condensin in the context of chromatin - P. Bernard
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Determining (1) the mechanisms that make chromatin suitable for condensin action in vivo,(2) the role of condensin at telomeres, and (3) the link between condensin and S phase.
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Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
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Comparative and Integrative Genomics of Organ Development - S.Pantalacci/M. Semon
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We compare genomes and transcriptomes to highlight general rules about the development and/or the evolution of organs.
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