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Physical Biology of Chromatin - D. Jost
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In close connection with experimental biology, our research addresses generic or specific biological questions on chromatin and gene regulation by developing physical and computational models. Particularly, we focus on the spatio-temporal dynamics of eukaryotic chromosomes. Our research tackles important questions regarding the coupling between 3D structure and functions of chromatin. Our objective is to provide some universal principles driving chromatin folding and regulation, while contextualizing our approaches to fundamental, specific problems of 3D genomics.
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Condensin in the context of chromatin - P. Bernard
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Determining (1) the mechanisms that make chromatin suitable for condensin action in vivo,(2) the role of condensin at telomeres, and (3) the link between condensin and S phase.
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Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
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Epigenetic regulation of cell identity and environmental stress responses - F. Palladino
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We are interested in understanding the role of conserved chromatin marks in the maintenance of germline identity and the response to environmental stress.
To adress these questions, we are using C. elegans as a model organism. We use a combination of genetic, biochemical and genome wide approaches.
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Presentation
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Epigenetic regulation during development
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