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Physical Biology of Chromatin - D. Jost
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In close connection with experimental biology, our research addresses generic or specific biological questions on chromatin and gene regulation by developing physical and computational models. Particularly, we focus on the spatio-temporal dynamics of eukaryotic chromosomes. Our research tackles important questions regarding the coupling between 3D structure and functions of chromatin. Our objective is to provide some universal principles driving chromatin folding and regulation, while contextualizing our approaches to fundamental, specific problems of 3D genomics.
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Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
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The ability of the genome to adopt a dynamic 3D organisation underlies most DNA transactions. The profound reorganisation of long chromatin fibres into rod-shaped chromosomes in mitosis is an iconic example of this structural dynamics. The main goal of our research is to understand the cellular mechanisms that take place at the chromatin level for the assembly of segregation-competent mitotic chromosomes. We use the fission yeast Schizosaccharomyces pombe and human cultured cells as model systems.
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Condensin in the context of chromatin - P. Bernard
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Determining (1) the mechanisms that make chromatin suitable for condensin action in vivo,(2) the role of condensin at telomeres, and (3) the link between condensin and S phase.
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Chromatin Dynamics in Mitotic Chromosome Assembly - P. Bernard
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Regulation of Genome Architecture and Dynamics of Splicing (ReGArDS) - D. Auboeuf and C. Bourgeois
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Our team is interested in the regulation of alternative splicing, the main process allowing to largely increase the functional diversity of proteins coded by a limited number of genes in higher organisms.
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