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Post-transcriptional regulation of gene expression in innate immunity.

Susan Carpenter, Emiliano P Ricci, Blandine C Mercier, Melissa J Moore, and Katherine A Fitzgerald (2014)

Nat Rev Immunol, 14(6):361-76.

Innate immune responses combat infectious microorganisms by inducing inflammatory responses, antimicrobial pathways and adaptive immunity. Multiple genes within each of these functional categories are coordinately and temporally regulated inresponse to distinct external stimuli. The substantial potential of these responses to drive pathological inflammation and tissue damage highlights the need for rigorous control of these responses. Although transcriptional control of inflammatory gene expression has been studied extensively, the importance of post-transcriptional regulation of these processes is less well defined. In thisReview, we discuss the regulatory mechanisms that occur at the level of mRNA splicing, mRNA polyadenylation, mRNA stability and protein translation, and thathave instrumental roles in controlling both the magnitude and duration of the inflammatory response.

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