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The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanism.

Jorge Vera-Otarola, Loretto Solis, Ricardo Soto-Rifo, Emiliano P Ricci, Karla Pino, Nicole D Tischler, Theophile Ohlmann, Jean-Luc Darlix, and Marcelo Lopez-Lastra (2012)

J Virol, 86(4):2176-87.

The small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein.In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggestthat translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.

 
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